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COO/COA

SRP2094

Fos-related antigen 1 human

Name: Fos-related antigen 1 human
Brand: SIGMA

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

Synonyme(s) :

FRA, FRA1, fra-1

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About This Item

Code UNSPSC :

12352202

Nomenclature NACRES :

NA.26

Source biologique

human

Produit recombinant

expressed in insect cells

Pureté

≥70% (SDS-PAGE)

Forme

frozen liquid

Poids mol.

~31.2 kDa

Conditionnement

pkg of 5 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Concentration

350 μg/mL

Couleur

colorless to clear

Numéro d'accès NCBI

NM_005438

Numéro d'accès UniProt

P15407

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... FOSL1(8061)

Actions biochimiques/physiologiques

The fos-related antigen 1 (Fra-1, or FosL1: Fos-like antigen 1) is a member of the Fos onco-protein family and a component of AP-1 transcription factor. Similar to other members of the family, Fra-1 contains a leucine zipper domain and a highly conserved C-terminal region. Transcription of Fra-1 gene is regulated by multiple cis-elements and 12-O-tetradecanoylphorbol-13-acetate (TPA). Fra-1 expression is associated with proliferation and invasiveness of breast cancer cells and other cancer cells.

Forme physique

Clear and colorless frozen liquid solution

Notes préparatoires

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes.

D R Cohen et al.

Genes & development, 3(2), 173-184 (1989-02-01)

fra-1 encodes a serum-inducible protein (Fra-1) that is antigenically related to Fos. We have characterized Fra-1 expression in serum-stimulated cells using antibodies raised against several regions of this protein. Fra-1, expressed transiently in COS cells or in serum-stimulated rat fibroblasts

Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation.

M Matsui et al.

Oncogene, 5(3), 249-255 (1990-03-01)

cDNA clones of human fos-related genes fra-1 and fra-2 were isolated by screening human c-DNA libraries with human fos DNA as a probe. We obtained human fra-1 cDNA clones that can code for a protein of 271 amino acid residues

Multiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cells.

Pavan Adiseshaiah et al.

The Journal of biological chemistry, 278(48), 47423-47433 (2003-09-19)

Recent studies indicate a potential role for Fra-1, a heterodimeric partner of activator protein 1 (AP1), in toxicant-induced epithelial injury, repair, and cellular transformation. Here, we have investigated the transcriptional regulation of fra-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) in human bronchial epithelial

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