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Key Documents

SRP2036

Sigma-Aldrich

BRG1, wild type human

recombinant, expressed in insect cells, ≥80% (SDS-PAGE)

Synonyme(s) :

BAF190, BRG1, FLJ39786, RTPS2, SNF2, SNF2-beta, SNF2L4, SNF2LB, SWI2, hSNF2b

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About This Item

Code UNSPSC :
12352200
Nomenclature NACRES :
NA.26

Source biologique

human

Produit recombinant

expressed in insect cells

Pureté

≥80% (SDS-PAGE)

Forme

frozen liquid

Poids mol.

~185 kDa

Conditionnement

pkg of 5 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Concentration

300 μg/mL

Couleur

clear
 colorless

Numéro d'accès NCBI

NM_003072

Numéro d'accès UniProt

P51532

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... SMARCA4(6597)

Actions biochimiques/physiologiques

The wild type human brahma-related gene 1 (Brg1) encodes a protein of 1,647 amino acids that contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription regulation. BRG1 is an essential component of the SWI/SNF chromatin remodeling complexes and implicated in multiple functions through its interaction with different proteins, including the tumor suppressor protein pRb, serine-threonine kinase LKB1, and other transcription factors. Although Brg1 is involved in chromatin remodeling as a complex with other SWI/SNF proteins, purified BRG1 itself is capable of remodeling mono-nucleosomes and nucleosomal arrays in vitro. Mutations of Brg1 have been found in multiple tumor cell lines.

Forme physique

Clear and colorless frozen liquid solution

Notes préparatoires

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

P A Khavari et al.
Nature, 366(6451), 170-174 (1993-11-11)
Sequence-specific DNA binding activators of gene transcription may be assisted by SWI2 (SNF2), which contains a DNA-dependent ATPase domain. We have isolated a human complementary DNA encoding a 205K nuclear protein, BRG1, that contains extensive homology to SWI2 and Drosophila
S Sif et al.
Genes & development, 12(18), 2842-2851 (1998-09-23)
During mitosis, chromatin is condensed into mitotic chromosomes and transcription is inhibited, processes that might be opposed by the chromatin remodeling activity of the SWI/SNF complexes. Brg1 and hBrm, which are components of human SWI/SNF (hSWI/SNF) complexes, were recently shown
C J Fryer et al.
Nature, 393(6680), 88-91 (1998-05-20)
The assembly of transcriptional regulatory DNA sequences into chromatin plays a fundamental role in modulating gene expression. The promoter of the mouse mammary-tumour virus (MMTV) is packaged into a regular array of nucleosomes when it becomes stably integrated into mammalian

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