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Key Documents

SRP2027

Sigma-Aldrich

E2F-1 (RBAP-1) human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

Synonyme(s) :

E2F-1, RBAP1, RBBP3, RBP3

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.26

Source biologique

human

Produit recombinant

expressed in insect cells

Pureté

≥70% (SDS-PAGE)

Forme

frozen liquid

Poids mol.

~48.6 kDa

Conditionnement

pkg of 5 μg

Concentration

400 μg/mL

Couleur

colorless to clear

Numéro d'accès NCBI

NM_005225

Numéro d'accès UniProt

Q01094

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... E2F1(189971)

Actions biochimiques/physiologiques

E2F was originally identified as a transcription factor mediating the transcription of adenovirus E2 gene. It is a heterodimer composed of two structurally related subunits, termed E2F and DP. E2F is encoded by at least five genes, E2F-1 through E2F-5, and DP is encoded by at least two genes, DP-1 and DP-2. All these genes (E2F-1 through E2F-5, DP-1 and DP-2) have been considered as members of the E2F gene family because they have a number of common structural and functional characteristics. Among those members of the E2F family, E2F-1 was the first E2F gene cloned and characterized. The E2F-1 protein has been shown to interact with RB both in vitro and in vivo. Although the E2F proteins can function as transcription factors by themselves, they should be considered as RB-mediators as well because almost every functional response of RB protein(s) requires the presence of E2F protein(s).

Forme physique

Clear and colorless frozen liquid solution

Notes préparatoires

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

S Bagchi et al.
Cell, 62(4), 659-669 (1990-08-24)
Adenovirus infection activates the E2F transcription factor, in part through the formation of a heteromeric protein complex involving a 19 kd E4 gene product that then allows cooperative and stable promoter binding. We now find that cellular factors are complexed
K Helin et al.
Cell, 70(2), 337-350 (1992-07-24)
The retinoblastoma protein (pRB) plays an important role in the control of cell proliferation, apparently by binding to and regulating cellular transcription factors such as E2F. Here we describe the characterization of a cDNA clone that encodes a protein with
W G Kaelin et al.
Cell, 70(2), 351-364 (1992-08-03)
An expression vector was modified to permit the rapid synthesis of purified, 32P-labeled, glutathione S-transferase (GST)-retinoblastoma (RB) fusion proteins. The products were used to screen lambda gt11 expression libraries, from which we cloned a cDNA encoding a polypeptide (RBAP-1) capable

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