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SML1869

Sigma-Aldrich

Delafloxacin

≥98% (HPLC)

Synonyme(s) :

1-(6-Amino-3,5-difluoro-2-pyridyl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-quinoline-3-carboxylic acid, ABT-492, WQ-3034

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About This Item

Formule empirique (notation de Hill):
C18H12ClF3N4O4
Numéro CAS:
189279-58-1
Poids moléculaire :
440.76
Numéro MDL:
MFCD09955301
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

DMSO: 20 mg/mL, clear

Température de stockage

2-8°C

Chaîne SMILES 

ClC1=C(N(C2=NC(N)=C(F)C=C2F)C=C(C(O)=O)C3=O)C3=CC(F)=C1N4CC(O)C4

InChI

1S/C18H12ClF3N4O4/c19-12-13-7(1-9(20)14(12)25-3-6(27)4-25)15(28)8(18(29)30)5-26(13)17-11(22)2-10(21)16(23)24-17/h1-2,5-6,27H,3-4H2,(H2,23,24)(H,29,30)

Clé InChI

DYDCPNMLZGFQTM-UHFFFAOYSA-N

Actions biochimiques/physiologiques

Delafloxacin is a fluoroquinolone antibiotic active against both Gram-negative and Gram-positive bacteria such as MRSA. Delafloxacin targets both DNA gyrase and topoisomerase IV, inhibiting DNA synthesis. Unlike most fluoroquinolones, delafloxacin is weakly acidic, which increases its potency in an acidic environments such as those existing in inflammatory cells and in skin and soft tissue infections. Delafloxacin shows good activity against most fluoroquinolone-resistant strains.
Delafloxacin is mostly prefered for the treatment of respiratory tract infections.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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In vivo Pharmacodynamic Target Assessment of Delafloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in the Murine Lung Infection Model.
Lepak A J and Andes D R
Antimicrobial Agents and Chemotherapy, 60(8), 4764?4769-4764?4769 (2016)
Françoise Van Bambeke
Future microbiology, 10(7), 1111-1123 (2015-06-30)
Delafloxacin is a fluoroquinolone lacking a basic substituent in position 7. It shows MICs remarkably low against Gram-positive organisms and anaerobes and similar to those of ciprofloxacin against Gram-negative bacteria. It remains active against most fluoroquinolone-resistant strains, except enterococci. Its
Robert K Flamm et al.
Antimicrobial agents and chemotherapy, 60(10), 6381-6385 (2016-07-28)
Delafloxacin, an investigational anionic fluoroquinolone, is active against a broad range of Gram-positive and Gram-negative bacteria. In this study, 200 Streptococcus pneumoniae (plus 30 levofloxacin-resistant isolates), 200 Haemophilus influenzae, and 100 Moraxella catarrhalis isolates selected primarily from the United States
Bela Kocsis et al.
Annals of clinical microbiology and antimicrobials, 15(1), 34-34 (2016-05-25)
Quinolones are potent antimicrobial agents with a basic chemical structure of bicyclic ring. Fluorine atom at position C-6 and various substitutions on the basic quinolone structure yielded fluoroquinolones, namely norfloxacin, ciprofloxacin, levofloxacin, moxifloxacin and numerous other agents. The target molecules

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