SML1295

RBC8

≥98% (HPLC)

• Synonyme(s) : 6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile
• Formule empirique (notation de Hill): C₂₅H₂₀N₄O₃
• Numéro CAS: 361185-42-4
• Poids moléculaire : 424.45
• Numéro MDL: MFCD03341241
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825769
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: NC1=C(C#N)C(C2=C(OC)C=CC(OC)=C2)C(C(C3=CC=C(C=CC=C4)C4=C3)=NN5)=C5O1
• InChI: 1S/C25H20N4O3/c1-30-17-9-10-20(31-2)18(12-17)21-19(13-26)24(27)32-25-22(21)23(28-29-25)16-8-7-14-5-3-4-6-15(14)11-16/h3-12,21H,27H2,1-2H3,(H,28,29)
• Clé InChI: CLMQBVUFKIKYLU-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

RBC8 is a selective inhibitor of the Ras-like GTPases RalA and RalB, downstream mediators of Ras signalling, without direct inihibition of Ras or RhoA activity. RBC8 binds to a site on the GDP-bound form of Ral, its inactive state, inhibiting the binding of Ral to its effectors, such as Ral-binding protein 1 (RALBP1; also known as RLIP760, which are involved in proliferation, survival, and metastasis of several human cancers. RBC8 inhibited growth in human luung cancer cell lines with IC₅₀ values of 2.0 μM in H2122 cells and 1.3 μM in H358 cells, and also inihbited tumor xenograft growth..

RBC8 is a selective inhibitor of the Ras-like GTPases RalA and RalB.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable