SML1215

Cuspin-1

≥98% (HPLC)

• Synonyme(s) : (5-Bromo-3-pyridinyl)(4-methylphenyl)methanone
• Formule empirique (notation de Hill) : C₁₃H₁₀BrNO
• Numéro CAS: 337932-29-3
• Poids moléculaire : 276.13
• Numéro MDL: MFCD00452965
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825725
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL, clear (warmed)
• Température de stockage: room temp
• Chaîne SMILES: CC(C=C1)=CC=C1C(C2=CC(Br)=CN=C2)=O
• InChI: 1S/C13H10BrNO/c1-9-2-4-10(5-3-9)13(16)11-6-12(14)8-15-7-11/h2-8H,1H3
• Clé InChI: AJZRSLVRFSCCIL-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Cuspin-1 (Chemical Upregulator of SMN Protein-1) is an upregulator of the Survival of Motor Neuron protein (SMN), necessary for survival of motor neurons. SMN is decreased in the neurodegenerative disease Spinal Muscular Atrophy (SMA), an autosomal recessive disease caused by a genetic defect in the SMN1 gene. SMA is the second leading cause of neuromuscular disease, after Duchenne muscular dystrophy. Cuspin-1 increased SMN levels by 50-100% in SMA patient fibroblast cells accompanied by an increase in the phosphorylation of Erk, suggesting inbvolvement of the Ras-Raf-MEK cascade.

Cuspin-1 (Chemical Upregulator of SMN Protein-1) is an upregulator of the Survival of Motor Neuron protein (SMN).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3