SML1211

SMANT hydrochloride

≥98% (HPLC)

• Synonyme(s) : N-(4-Bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride
• Formule empirique (notation de Hill) : C₁₆H₂₃BrN₂O · HCl
• Numéro CAS: 1177600-74-6
• Poids moléculaire : 375.73
• Numéro MDL: MFCD06620515
• Code UNSPSC : 51111800
• ID de substance PubChem : 329825721
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: H₂O: 1 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: BrC1=CC=C(NC(CCN2CC(C)CC(C)C2)=O)C=C1.Cl
• InChI: 1S/C16H23BrN2O.ClH/c1-12-9-13(2)11-19(10-12)8-7-16(20)18-15-5-3-14(17)4-6-15;/h3-6,12-13H,7-11H2,1-2H3,(H,18,20);1H
• Clé InChI: XQESCHFXROUCOQ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

SMANT is a Hedgehog pathway antagonist, a Smoothened antagonist that behaves similarly against normal cancer smoothened and the M2 mutant. In a study comparing activities among the currently known smoothened/Hedgehog antagonists, SMANT behaves differently, binding to another Smo site different to that bound by other compounds.

SMANT is a Hedgehog pathway antagonist; a Smoothened antagonist.

Informations sur la sécurité

• Pictogrammes: GHS09
• Mentions de danger: H411
• Conseils de prudence: P273 - P391 - P501
• Classification des risques: Aquatic Chronic 2
• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable