SML0442

ML239

≥98% (HPLC)

• Synonyme(s) : (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide
• Formule empirique (notation de Hill): C₁₃H₁₀Cl₃N₃O₂
• Numéro CAS: 1378872-36-6
• Poids moléculaire : 346.60
• Numéro MDL: MFCD23098913
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824724
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 15 mg/mL (clear solution)
• Température de stockage: 2-8°C
• Chaîne SMILES: Clc1cc(Cl)c(OCC(=O)N\N=C\c2ccc[nH]2)c(Cl)c1
• InChI: 1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+
• Clé InChI: NVEDPFICKAIHKD-NGYBGAFCSA-N

Description

Application

ML239 has been used as a proble in cellular lipid profiling.

Actions biochimiques/physiologiques

ML239 decreases the saturated and monounsaturated lysophosphatidylethanolamines in lung cancer cells and is toxic to breast cancer cells. ML239 may elicit toxicity by modulating the nuclear factor−κB (NF-κB) associated pathways.

ML239 is an inhibitor of breast cancer stem cells found from a screen using stem cell-like human mammary epithelial cells (HMLE). ML239 inhibited cancer stem cells with an IC₅₀ of 1.16 μM with 24-fold selectivity against the control cell line.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302 + H312 + H332,H315,H319,H335,H400
• Conseils de prudence: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable