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SML0069

Sigma-Aldrich

NSC 33994

≥98% (HPLC)

Synonyme(s) :

(E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI), 4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}, G6

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About This Item

Formule empirique (notation de Hill):
C28H42N2O2
Numéro CAS:
82058-16-0
Poids moléculaire :
438.65
Numéro MDL:
MFCD20488055
Code UNSPSC :
12352200
ID de substance PubChem :
329825133
Nomenclature NACRES :
NA.77

Essai

≥98% (HPLC)

Forme

powder

Couleur

white to tan

Solubilité

DMSO: ≥25 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

CCN(CC)Cc1cc(ccc1O)C(\CC)=C(/CC)c2ccc(O)c(CN(CC)CC)c2

InChI

1S/C28H42N2O2/c1-7-25(21-13-15-27(31)23(17-21)19-29(9-3)10-4)26(8-2)22-14-16-28(32)24(18-22)20-30(11-5)12-6/h13-18,31-32H,7-12,19-20H2,1-6H3/b26-25+

Clé InChI

QFNJFVBKASKGEU-OCEACIFDSA-N

Application

NSC 33994 may be used in Jak2-mediated cell signaling studies.

Actions biochimiques/physiologiques

NSC 33994 is a potent and specific Jak2 inhibitor that inhibits a notorious mutation, Jak2-V617F, found in large number of myeloproliferative neoplasms.
Potent and specific Jak2 inhibitor effective against Jak2-V617F mutation

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
061M4619V

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Zhen Wang et al.
Scientific reports, 8(1), 9509-9509 (2018-06-24)
The exon junction complex (EJC) deposited on spliced mRNAs, plays a central role in the post-transcriptional gene regulation and specific gene expression. The EJC core complex is associated with multiple peripheral factors involved in various post-splicing events. Here, using recombinant
Yuehui Wang et al.
Methods (San Diego, Calif.), 173, 32-43 (2019-06-22)
Influx evidences show that red long non-coding RNAs (lncRNAs) play important roles in various critical biological processes, and they afffect the development and progression of various human diseases. Therefore, it is necessary to precisely identify the lncRNA-disease associations. The identification
S Khademvatan et al.
Journal of helminthology, 93(2), 131-138 (2018-04-03)
Cystic echinococcosis (CE) caused by Echinococcus granulosus sensu lato (s.l.) is a significant zoonosis, especially in developing countries of the Middle East, with many studies focusing on CE genotypes in Iran. We performed a systematic review to determine the exact
Juliet Chepngeno et al.
Veterinary research, 50(1), 84-84 (2019-10-24)
Rotavirus C (RVC) has been detected increasingly in humans and swine in different countries, including the US. It is associated with significant economic losses due to diarrheal disease in nursing piglets. In this study we aimed: (1) to determine the
Kimberly McCoy et al.
ACS nano, 12(4), 3541-3550 (2018-03-21)
Bottom-up construction of mesoscale materials using biologically derived nanoscale building blocks enables engineering of desired physical properties using green production methods. Virus-like particles (VLPs) are exceptional building blocks due to their monodispersed sizes, geometric shapes, production ease, proteinaceous composition, and
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