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SAB4504574

Sigma-Aldrich

Anti-phospho-Caspase 8 (pTyr380) antibody produced in rabbit

affinity isolated antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 55 kDa

Espèces réactives

mouse, human, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q14790

Numéro d'accès UniProt

Q14790

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pTyr380)

Informations sur le gène

human ... CASP8(841)

Description générale

Caspase-8 (CASP8) is a member of the cysteine aspartate-specific proteases family. It is produced in the cell as procaspase-8, a sluggish zymogen. Procaspase-8 has a long prodomain, carrying two major protein interaction domains, DED1 and DED2, followed by one large (p18) and one small (p10) catalytic subunit. CASP8 is mapped to human chromosome 2q33.

Immunogène

The antiserum was produced against synthesized peptide derived from human Caspase 8 around the phosphorylation site of Tyr380.

Immunogen Range: 346-395

Actions biochimiques/physiologiques

Caspase-8 (CASP8) is involved in apoptosis, inflammation and cellular differentiation. It activates programmed cell death, after death receptor ligation. Casp8 is essential for the clonal expansion of T and B cell. It also participates in lymphocyte homeostasis.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Structure and chromosome localization of the human CASP8 gene.
Jose GA, et al.
Gene, 226(2), 225-232 (1999)
Dwayne G Stupack
Cancer letters, 332(2), 133-140 (2010-09-08)
Caspase-8 is an apical caspase which initiates programmed cell death following death receptor ligation. This central role in apoptosis has prompted significant clinical interest in regulating caspase-8 expression and proteolytic activity. However, caspase-8 has also been found to play a
Caspase-8, association with Alzheimer?s Disease and functional analysis of rare variants.
Jan R, et al.
PLoS ONE, 12(10), e0185777-e0185777 (2017)
Functions of Caspase 8: the Identified and the Mysterious.
Guy SS and Craig MW
Seminars in Immunology, 26(3), 246?252-246?252 (2014)

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