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SAB4503999

Sigma-Aldrich

Anti-phospho-TIE2 (pTyr1108) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-CD202B, Anti-GLC3E, Anti-TIE-2, Anti-VMCM, Anti-VMCM1

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 125 kDa

Espèces réactives

mouse, rat, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q02763

Numéro d'accès UniProt

Q02763

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pTyr1108)

Informations sur le gène

human ... TEK(7010)

Description générale

The TIE2 (TEK receptor tyrosine kinase) is also termed as TEK (tyrosine-protein kinase receptor). This gene is located on human chromosome 9p21.2. It is expressed in the Schlemm′s canal endothelial of the eye. TIE2 belongs to the receptor tyrosine kinases family.

Immunogène

The antiserum was produced against synthesized peptide derived from human TIE2 around the phosphorylation site of Tyr1108.

Immunogen Range: 1074-1123

Actions biochimiques/physiologiques

Tie-2 (TEK receptor tyrosine kinase) protein induces angiogenesis and supports endothelial cell survival, upon binding of angiopoietin-1 (an endothelial growth factor) to the receptor. This gene is necessary for Schlemm′s canal formation. This gene regulates vascular homeostasis by involving in auto or transphosphorylation. Tie-2 is essential for the growth of vascular structures during embryogenesis.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation
Hossain MB, et al.
Molecular and Cellular Biology (2017)
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
Davis S, et al.
Cell, 87(7), 1161-1169 (1996)
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
Suri C, et al.
Cell, 87(7), 1171-1180 (1996)
Hui Liu et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 54(10), e11028-e11028 (2021-07-22)
Engeletin is a natural derivative of Smilax glabra rhizomilax that exhibits anti-inflammatory activity and suppresses lipid peroxidation. In the present study, we sought to elucidate the mechanistic basis for the neuroprotective and pro-angiogenic activity of engeltin in a human umbilical
Hisashi Takada et al.
Cancer science, 96(2), 100-110 (2005-02-23)
We performed genome-wide screening for deoxyribonucleic acid copy-number aberrations in 31 gastric cancer (GC) cell lines by using custom-made comparative genomic hybridization (CGH)-array. Copy-number gains were frequently detected at 1q, 3q, 5p, 7p, 7q, 8q, 11q, 17q, 20p, 20q, Xp
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