SAB4502492
Anti-NDRG3 antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
Protein NDRG3
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 41 kDa
Espèces réactives
human, mouse, rat
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... NDRG3(57446)
Description générale
NDRG3 (N-myc downstream-regulated gene 3 protein) is a novel member of N-myc down-regulated gene (NDRG) family mapped to human chromosomal location 20q11.21-q11.23. It is abundantly expressed in brain, prostate, ovary, and testis tissues. It is localized to the outer layers of seminiferous epithelium.
Immunogène
The antiserum was produced against synthesized peptide derived from human NDRG3.
Immunogen Range: 206-255
Immunogen Range: 206-255
Application
Anti-NDRG3 antibody produced in rabbit is suitable for immunohistochemistry and western blot.
Actions biochimiques/physiologiques
N-myc downstream-regulated gene 3 protein (NDRG3) is involved in prostate cancer cell growth in vitro and in vivo. It acts as an androgen regulated and prostate enriched gene during controlling of cancer cell growth. Thus, overexpression of NDRG3 has been linked to the malignant phenotype of tumors. In hepatitis B virus (HBV)-related hepatocellular carcinoma cell line, NDRG3 gene is inversely expressed with the miR-122 expression. Thus, it has been reported that in conjugation with miR-122, NDRG3 can be a potential therapeutic marker for hepatocellular carcinoma (HCC). Prominent localization of NDRG3 in the epithelium cells indicate its role in spermatogenesis. It also plays an important role in lactate-induced hypoxia signaling pathway in hypoxia. Its protein level expression in cell is negatively regulated by oxygen, whereas, whereas excess lactate produced under prolonged hypoxia blocks its proteasomal degradation by binding to NDRG3.
Caractéristiques et avantages
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Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Kyung Chan Park et al.
BMB reports, 48(6), 301-302 (2015-05-06)
Hypoxia is associated with many pathological conditions as well as the normal physiology of metazoans. We identified a lactate-dependent signaling pathway in hypoxia, mediated by the oxygen- and lactate-regulated protein NDRG family member 3 (NDRG3). Oxygen negatively regulates NDRG3 expression
Xianghu Qu et al.
Molecular and cellular biochemistry, 229(1-2), 35-44 (2002-04-09)
NDRG1 (N-Myc downstream regulated) is upregulated during cell differentiation, repressed by N-myc and c-myc in embryonic cells, and suppressed in several tumor cells. A nonsense mutation in the NDRG1 gene has been reported to be causative for hereditary motor and
Chun-Guang Fan et al.
Oncology reports, 26(5), 1281-1286 (2011-07-05)
microRNAs (miRNAs) are short, non-coding RNAs with post-transcriptional regulatory functions that participate in diverse biological pathways. miR-122, a liver-specific miRNA, has been found to be down-regulated in hepatocellular carcinoma (HCC) and HCC-derived cell lines. In this study, miR-122 was down-regulated
Weiqun Wang et al.
International journal of cancer, 124(3), 521-530 (2008-11-01)
NDRG3 belongs to the N-myc down-regulated gene (NDRG) family that contains 4 paralogs: NDRG1, -2, -3 and -4. The function of NDRG3 and its relationship to cancer has not been studied. We herein report our examination of the expression and
W Zhao et al.
Biochimica et biophysica acta, 1519(1-2), 134-138 (2001-06-19)
We report the cloning and expression pattern of a novel N-myc downstream-regulated gene 3 (NDRG3), located on human chromosome 20q11.21-11.23. The NDRG3 cDNA is 2588 base pair in length, encoding a 363 amino acid polypeptide highly related to mouse Ndr3
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