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SAB4501137

Sigma-Aldrich

Anti-Glucagon antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Glicentin, Glicentin-related polypeptide, Glucagon-like peptide 1(7-37), Glucagon-like peptide 1(GLP-1), Oxyntomodulin

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About This Item

Numéro MDL:
MFCD00162325
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 20 kDa

Espèces réactives

human, rat, mouse

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

Numéro d'accès NCBI

P01275

Numéro d'accès UniProt

P01275

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... GCG(2641)

Description générale

Anti-Glucagon antibody detects endogenous levels of total Glucagon protein.
Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone. It is a 30-amino acid peptide, that is generated by the intestinal epithelial endocrine L-cells. it is mapped to human chromosome 2q24.

Immunogène

The antiserum was produced against synthesized peptide derived from human Glucagon.

Immunogen Range: 61-110

Application

Anti-glucagon antibody has been used in immunostaining and immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Actions biochimiques/physiologiques

Glucagon-like peptide-1 (GLP-1) increases glucose-dependent insulin secretion and terminates the liberation of glucagon. It acts as a physiological regulator of appetite and food intake. GLP-1 also helps to prevent the gastrointestinal movement and secretion.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Expression and regulation of chemokines in murine and human type 1 diabetes
Sarkar SA, et al.
Diabetes, 61(2), 436-446 (2012)
Glucagon-like Peptide-1 Analogues Inhibit Proliferation and Increase Apoptosis of Human Prostate Cancer Cells in vitro
Li XN, et al.
Experimental and Clinical Endocrinology & Diabetes, 125(02), 91-97 (2017)
Reg3? Overexpression Protects Pancreatic Beta-Cells From Cytokine-Induced Damage and Improves Islet Transplant Outcome
Ding Y, et al.
Molecular Medicine, 20(1), 548-548 (2014)
Huan Zhao et al.
Nature metabolism, 3(3), 352-365 (2021-03-17)
It has been suggested that new beta cells can arise from specific populations of adult pancreatic progenitors or facultative stem cells. However, their existence remains controversial, and the conditions under which they would contribute to new beta-cell formation are not
The Physiology of Glucagon-like Peptide 1
Holst JJ
American Physiological Society, 87(4), 1409-1439 (2007)
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