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Key Documents

SAB4500896

Sigma-Aldrich

Anti-COPZ1 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

ζ1-COP, CGI-120, COPZ, coatomer protein complex, subunit ζ 1

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 20 kDa

Espèces réactives

human, mouse

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P61923

Numéro d'accès UniProt

P61923

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... COPZ1(22818)

Catégories apparentées

Description générale

Anti-COPZ1 Antibody detects endogenous levels of total COPZ1 protein.

COPZ1 (coatomer protein complex ζ1) codes for a subunit of coatomer protein complex 1 (COPI). It is a secretory vesicle coat protein. It is located on human chromosome 12q13.

Immunogène

The antiserum was produced against synthesized peptide derived from human COPZ1.

Immunogen Range: 11-60

Application

Anti-COPZ1, N-Terminal antibody has been used in immunohistochemistry , immunofluorescence and western blotting.

Actions biochimiques/physiologiques

COPZ1 (coatomer protein complex ζ1) participates in intracellular traffic and autophagy, and endosome maturation. Suppression of COPZ1 promotes apoptosis in proliferating and nondividing tumor cells.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the phosphatidylinositol-3-kinase/Akt pathway
Narkis G, et al.
American Journal of Human Genetics, 81, 589-595 (2007)
Targeting COPZ1 non-oncogene addiction counteracts the viability of thyroid tumor cells
Anania MC, et al.
Cancer Letters, 410, 201-211 (2017)
Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ? 2 renders tumor cells dependent on its paralogous gene COPZ1
Shtutman M, et al.
Proceedings of the National Academy of Sciences of the USA, 108, 12449-12454 (2011)
Maria Chiara Anania et al.
Cancer letters, 410, 201-211 (2017-09-28)
Thyroid carcinoma is generally associated with good prognosis, but no effective treatments are currently available for aggressive forms not cured by standard therapy. To find novel therapeutic targets for this tumor type, we had previously performed a siRNA-based functional screening
Eileen Sun et al.
Journal of virology, 87(5), 2673-2685 (2012-12-21)
As an obligate pathogen, influenza virus requires host cell factors and compartments to mediate productive infection and to produce infectious progeny virus. Recently, several small interfering RNA (siRNA) knockdown screens revealed influenza virus host dependency proteins, all of which identified

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