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SAB4500437

Sigma-Aldrich

Anti-Claudin 7 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

CEPTRL2, claudin 7, claudin 9, claudin-1, claudin-7

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 22 kDa

Espèces réactives

human, rat, mouse

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

O95471

Numéro d'accès UniProt

O95471

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CLDN7(1366)

Catégories apparentées

Description générale

Anti-Claudin 7 Antibody detects endogenous levels of total Claudin 7 protein.
Claudin 7 is a tight junction membrane protein that belongs to claudins (cld) family. It is upregulated at high level in the upper gastrointestinal tract and the liver. It is located on human chromosome 17p13.

Immunogène

The antiserum was produced against synthesized peptide derived from human Claudin 7.

Immunogen Range: 162-211

Actions biochimiques/physiologiques

In HCC827 and NCI-H358 lung cancer cells, suppression of claudin-7 decreases the expression of integrin β1. Claudins are important constituents of tight junctions (TJ) in the upper region of epithelial cells.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

The claudins
Lal-Nag M and Morin P J
Genome Biology (2009)
A non-tight junction function of claudin-7-Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment
Lu Z, et al.
Molecular Cancer (2015)
Harold Love et al.
Tissue engineering. Part A, 26(19-20), 1091-1098 (2020-04-22)
Patient-oriented applications of cell culture include cell therapy of organ failure like chronic renal failure. Clinical deployment of a cell-based device for artificial renal replacement requires qualitative and quantitative fidelity of a cultured cell to its in vivo counterpart. Active
The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities
Heiler S, et al.
Cell communication and signaling : CCS (2015)
Sijo Mathew et al.
Development (Cambridge, England), 144(22), 4148-4158 (2017-10-11)
Kidney collecting system development requires integrin-dependent cell-extracellular matrix interactions. Integrins are heterodimeric transmembrane receptors consisting of α and β subunits; crucial integrins in the kidney collecting system express the β1 subunit. The β1 cytoplasmic tail has two NPxY motifs that

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