SAB4300830
Anti-UCN antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
UI, UROC
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Espèces réactives
rat, human, mouse
Concentration
0.7 mg/mL
Technique(s)
immunohistochemistry: 1:25- 1:100
Isotype
IgG
Numéro d'accès
NP_003344.1
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... UCN(7349)
Description générale
Urocortin (UCN) belongs to the hypothalamic hormone corticotrophin-releasing factor (CRF) family. UCN has 45% homology to CRF. UCN is expressed in brain, placenta, lymphocytes and heart. In human chromosome, the gene UCN is localized on 2p23.3.
Spécificité
The antibody detects endogenous levels of total UCN protein.
Immunogène
Synthetic peptide corresponding to residues near the C terminal of human urocortin
Application
Anti-UCN antibody produced in rabbit has been used in immunohistochemical analysis.
Actions biochimiques/physiologiques
Urocortin (UCN1) is a key protein involved in regulating hypothalamic-pituitary-adrenal axis and modulating stress responses. Ucn1 is associated with both G-protein coupled CRF receptors and CRF binding proteins. UCN increases the heart rate, cardiac output, and coronary blood flow according to the dosage. UCN protects cardiac myocytes from cell death due to stress. Ucn upregulates p42/p44 mitogen activated protein kinase (MAPK) signalling pathway and protects the heart from reperfusion injury. High levels of Ucn mRNA have been observed in the Edinger−Westphal (EW) nucleus, associated with alcohol and drug addiction. Ucn delays the gastric emptying and reduces the food intake and thus regulates the body weight. Ucn enhances anxiogenic-like or stress-like effect. Ucn causes degranulation of mast cells and increases vascular permeability in response to stress. Ucn is found to be associated with stress induced atopic dermatitis or psoriasis.
Caractéristiques et avantages
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Forme physique
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Urocortin protects the heart from reperfusion injury via upregulation of p42/p44 MAPK signaling pathway
Schulman D, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 52(4), H1481-H1488 (2002)
Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors
Singh LK, et al.
Journal of Pharmacology and Experimental Therapeutics, 288(3), 1349-1356 (1999)
W J Giardino et al.
Translational psychiatry, 7(1), e1021-e1021 (2017-02-01)
Midbrain neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) are activated by alcohol, and enriched with stress-responsive neuropeptide modulators (including the paralog of corticotropin-releasing factor, urocortin-1). Evidence suggests that EWcp neurons promote behavioral processes for alcohol-seeking and consumption, but a
A role for corticotropin releasing factor and urocortin in behavioral responses to stressors
Koob GF and Heinrichs SC
Brain Research, 848(1-2), 141-152 (1999)
Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system
Giardino WJ, et al.
Translational Psychiatry, 7(1), e1021-e1021 (2017)
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