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SAB4300470

Sigma-Aldrich

Anti-CTNNB1 (Ab-33) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-CTNNB antibody produced in rabbit, Anti-DKFZp686D02253 antibody produced in rabbit, Anti-FLJ25606 antibody produced in rabbit, Anti-FLJ37923 antibody produced in rabbit, Anti-catenin (cadherin-associated protein), beta 1, 88kDa antibody produced in rabbit

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

~92 kDa

Espèces réactives

human, rat, mouse

Concentration

1 mg/mL

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

Isotype

IgG

Séquence immunogène

(L-D-S-G-I)

Numéro d'accès NCBI

Numéro d'accès UniProt

Application(s)

research pathology

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CTNNB1(1499)

Catégories apparentées

Description générale

Catenin beta-1 (CTNNB1) encoding β-catenin, belongs to armadillo-repeat family. In human chromosome, the gene CTNNB1 is localized on 3p22.1.

Immunogène

Peptide sequence around aa. 31-35 (L-D-S-G-I), according to the protein CTNNB1.

Actions biochimiques/physiologiques

Catenin beta-1 (CTNNB1) is a signalling molecule in the nucleus and anchors actin cytoskeleton to cadherin-based adherens junctions. Phosphorylation causes dissociation of β-catenin from E-cadherin and degradation by proteasome pathway. β-catenin is a key molecule in wingless/integrated (wnt) signalling. β-catenin forms a complex with kindlin 2 and T-cell factor 4 (TCF4) to regulate wnt target gene expression. Mutations in adenomatous polyposis coli (APC) and CTNNB1 gene affects β-catenin intracellular localization and stability, contributing to aberrant expression of wnt/β-catenin in malignant melanoma. β-catenin is a major oncoprotein, which downregulates death associated protein kinase 2 (Dapk2) and inhibits anoikis of cancer cells. β-catenin expression is suppressed and its downstream gene transcription function is regulated by a tumor suppressor protein fragile histidine triad (Fhit). High expression of mucin 1 (MUC1), translocates β-catenin out of the nucleus and inhibits β-catenin regulated cell proliferation. Somatic mutations of CTNNB1 in glycogen synthase kinase 3β−casein kinase 1 (GSK-3β−CK1) phosphorylation site results in loss of phosphorylation of β-catenin. This causes aberrant wnt-signalling and leads to adrenocortical adenomas and adrenocortical carcinoma.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Description de la cible

Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization
Fiset A, et al.
Cellular Signalling, 23(5), 911-919 (2011)
Pregnancy, primary aldosteronism, and adrenal CTNNB1 mutations
Teo AED, et al.
The New England Journal of Medicine, 373(15), 1429-1436 (2015)
The tumor suppressor HINT1 regulates MITF and beta-catenin transcriptional activity in melanoma cells
Genovese G, et al.
Cell Cycle, 11(11), 2206-2215 (2012)
MUC1 inhibits cell proliferation by a beta-catenin-dependent mechanism
Lillehoj EP, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1773(7), 1028-1038 (2007)
Molecular genetic analysis of malignant melanomas for aberrations of the WNT signalling pathway genes CTNNB1, APC, ICAT and BTRC
Reifenberger J, et al.
International Journal of Cancer. Journal International Du Cancer, 100(5), 549-556 (2002)

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