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SAB4300397

Sigma-Aldrich

Anti-MYOD1 (Ab-200) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Anti-MYF3 antibody produced in rabbit, Anti-MYOD antibody produced in rabbit, Anti-PUM antibody produced in rabbit, Anti-bHLHc1 antibody produced in rabbit, Anti-myogenic differentiation 1 antibody produced in rabbit

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About This Item

Numéro MDL:
MFCD01323984
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

~40 kDa

Espèces réactives

mouse, human, rat

Concentration

1 mg/mL

Technique(s)

western blot: 1:500-1:1000

Isotype

IgG

Séquence immunogène

(A-S-S-P-R)

Numéro d'accès NCBI

NP_002469.2

Numéro d'accès UniProt

P15172

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... MYOD1(4654)

Description générale

MYOD1 (myogenic differentiation 1) gene codes for a nuclear protein, that is a member of the basic helix-loop-helix (bHLH) family of transcription factors and the myogenic factors subfamily. It is located on human chromosome 11p15.1.

Immunogène

Peptide sequence around aa. 198!202 (A-S-S-P-R), according to the protein MYOD1.

Actions biochimiques/physiologiques

Lack of MyoD (myogenic differentiation) results in a perinatally lethal fetal akinesia. It brings histone-modifying enzymes, which help to induce muscle differentiation.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Description de la cible

MyoD encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis.

Forme physique

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Deficiency of the myogenic factor MyoD causes a perinatally lethal fetal akinesia
Watson CM, et al.
Journal of medical Genetics, 53(4), 264-269 (2016)
Katalin Gyurina et al.
International journal of molecular sciences, 24(23) (2023-12-09)
Stimulation of thermogenesis by inducing uncoupling protein 1 (UCP1) expression in adipocytes is thought to promote weight loss by increasing energy expenditure, and it is postulated that the human newborn has thermogenic subcutaneous fat depots. However, it remains unclear whether
Manuela Dos Santos et al.
Advances in rheumatology (London, England), 62(1), 27-27 (2022-07-23)
Clinical evidence of skeletal muscle involvement is not uncommon in systemic lupus erythematosus (SLE). Because of the poor understanding of signaling pathways involved in SLE muscle wasting, the  aim of this study was to evaluate the effects of vitamin D supplementation
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations
Kohsaka S, et al.
Nature Genetics, 46(6), 595-600 (2014)
Narasimhan P Agaram et al.
Genes, chromosomes & cancer, 53(9), 779-787 (2014-05-16)
Sclerosing and spindle cell rhabdomyosarcoma (RMS) are rare types of RMS recently reclassified as a stand-alone pathologic entity, separate from embryonal RMS (ERMS). Although sclerosing and spindle cell RMS share clinical and morphologic features, a pathogenetic link based on shared
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