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SAB4200435

Anti-COG7 antibody produced in rabbit

Name: Anti-COG7 antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody

Synonyme(s) :

Anti-CDG2E, Anti-Component of oligomeric golgi complex 7

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About This Item

Code UNSPSC :

12352203

Nomenclature NACRES :

NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~86 kDa

Espèces réactives

mouse, rat, human

Concentration

~1.0 mg/mL

Technique(s)

immunoprecipitation (IP): 5-10 μg using lysates of human HeLa cells.
indirect immunofluorescence: 1-2 μg/mL using human HeLa cells.
western blot: 2.5-5.0 μg/mL using whole extracts of mouse LA-4 and rat PC12 cells.

Numéro d'accès UniProt

P83436

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... COG7(91949)
mouse ... Cog7(233824)
rat ... Cog7(293456)

Description générale

Conserved Oligomeric Golgi complex 7 (COG7) protein belongs to the COG complex. COG complex is composed of eight distinct subunits organized in two heterotrimeric groups, COG2, 3, 4 and COG5, 6, 7 which are linked via a dimeric group formed by COG1 and COG8. COG complex is an evolutionarily conserved multi-subunit protein complex. The COG7 gene is located on the human chromosome at 16p12.2.

Spécificité

Anti-COG7 recognizes human, mouse and rat COG7.

Immunogène

peptide corresponding to an internal region of human COG7, conjugated to KLH. The corresponding sequence is identical in mouse and rat COG7.

Application

Anti-COG7 antibody produced in rabbit may be used in:

immunoblotting
immunoprecipitation
immunofluorescence

Actions biochimiques/physiologiques

Conserved Oligomeric Golgi complex (COG) modulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells. COG7 protein is involved in retrograde vesicular trafficking. Mutations in the COG7 gene leads to type IIe congenital disorder of glycosylation.

Forme physique

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Stockage et stabilité

For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

A new mutation in COG7 extends the spectrum of COG subunit deficiencies.

Renate Zeevaert et al.

European journal of medical genetics, 52(5), 303-305 (2009-07-07)

We describe a patient homozygous for a novel mutation in COG7, coding for one of the subunits of the Conserved Oligomeric Golgi complex, involved in retrograde vesicular trafficking. His brother showed a similar clinical syndrome and glycosylation defect but no

A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia.

Eva Morava et al.

European journal of human genetics : EJHG, 15(6), 638-645 (2007-03-16)

We describe the clinical and biochemical characteristics in three patients from two different families diagnosed with Congenital Disorder of Glycosylation type IIe owing to a defect in Conserved Oligomeric Golgi complex (COG)7; one of the eight subunits of the COG.

A suite of novel human spermatozoal RNAs.

G Charles Ostermeier et al.

Journal of andrology, 26(1), 70-74 (2004-12-22)

We recently described a complex population of spermatozoal coding RNAs that are delivered to the oocyte on fertilization. These are derived throughout spermatogenesis, representing a record of past events. Recently, evidence has been provided that micro-RNAs are present in testes

Comparative analyses of the Conserved Oligomeric Golgi (COG) complex in vertebrates.

Rita Quental et al.

BMC evolutionary biology, 10, 212-212 (2010-07-17)

The Conserved Oligomeric Golgi (COG) complex is an eight-subunit assembly that localizes peripherally to Golgi membranes and is involved in retrograde vesicular trafficking. COG subunits are organized in two heterotrimeric groups, Cog2, -3, -4 and Cog5, -6, -7, linked by

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