SAB4200358

Anti-PLAUR antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonyme(s) : Anti-CD87, Anti-U-PAR, Anti-UPAR, Anti-URKR, Anti-Urokinase receptor, Anti-plasminogen activator
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 45/50 kDa
• Espèces réactives: human
• Concentration: ~1.0 mg/mL
• Technique(s): indirect immunofluorescence: 1-2 μg/mL using human HeLa cells.; western blot: 0.5-1.0 μg/mL using whole extracts of HEK-293T cells over-expressing human PLAUR.
• Numéro d'accès UniProt: Q03405
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PLAUR(5329)

Description

Description générale

Plasminogen activator urokinase receptor (PLAUR)/ urokinase plasminogen activator receptor (uPAR), a member of Ly6/ neurotoxin receptor family, is a heavily glycosylated glycosyl-phosphatidylinositol (GPI)-anchored cell-surface receptor. It is comprised of serine protease uPA, specific inhibitors (plasminogen activator inhibitors 1 and 2) and three internally disulfide-bonded domains (D1, D2 and D3).

Immunogène

peptide corresponding to a sequence at the C-terminus of human PLAUR, conjugated to KLH. The corresponding sequence is identical in monkey PLAUR.

Application

Anti-PLAUR antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Actions biochimiques/physiologiques

Plasminogen activator urokinase receptor (PLAUR)/ urokinase plasminogen activator receptor (uPAR) acts as a receptor for urokinase plasminogen activator (uPA). It localizes and promotes plasmin formation. uPAR influences many normal and pathological processes related to cell surface plasminogen activation, degradation of the extracellular matrix, cell migration, leukocyte adhesion, chemotaxis and signal transduction during leukocyte recruitment from the circulation to extravascular sites of inflammation. It is implicated as an anti-cancer target. uPAR is involved in epilepsy, language, cognition, communication and central nervous system disorders.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable