SAB2500422

Anti-FOXP3/Scurfin antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Synonyme(s) : Anti-AIID, Anti-Forkhead box P3, Anti-IPEX, Anti-JM2, Anti-SCURFIN
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: goat
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Espèces réactives: human
• Technique(s): flow cytometry: suitable; immunocytochemistry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• Numéro d'accès UniProt: Q9BZS1
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... FOXP3(50943)

Description

Description générale

Forkhead box P3 (FOXP3) is a transcription factor and part of the forkhead family. It possesses three α helices and three β strands. The protein has an amino-terminal region, a central zinc finger, a leucine zipper domain and the carboxyl-terminal region has a forkhead domain. The gene encoding this protein is localized on human chromosome Xp11.23.

Immunogène

Peptide with sequence SQRPSRCSNPTPGP from the C Terminus of the protein sequence according to NP_054728.2.

Actions biochimiques/physiologiques

Forkhead box P3 (FOXP3) associates with nuclear factor of activated T cells (NFAT) and nuclear factor κ B (NF-κB). It has a crucial role in the cellular differentiation of regulatory T cells. Alterations in the protein expression have been associated with immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. FOXP3 has a role in tumor growth and cancer.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable