S1190

Anti-SLIPR/MAGI-3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Numéro MDL: MFCD03792040
• Code UNSPSC : 12352203

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 140-160 kDa
• Espèces réactives: rat
• Technique(s): indirect immunofluorescence: 2.0 μg/mL using 293T cells transfected with recombinant Slipr.; microarray: suitable; western blot (chemiluminescent): 1.0 μg/mL using extracts of 293T cells transfected with recombinant Slipr
• Numéro d'accès UniProt: Q9JK71
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: rat ... Magi3(245903)

Description

Description générale

MAGI-3 possesses a guanylate-kinase-like region, six PDZ and two WW domains. This gene is located on human chromosome 1p13.

The MAGUK (Membrane Associated Guanylate kinase) family of proteins localize to regions of cell-cell contact, such as tight junctions in epithelial cells and synaptic junctions in neurons, and are believed to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.²

MAGI-3 (also termed SLIPR) was identified in a two hybrid screening as a protein interacting with the tumor suppressor PTEN,⁶ and Receptor Tyrosine Phosphatase β (RPTPβ).⁷

Spécificité

Staining by immunoblotting and immunofluorescence is specifically inhibited by the immunizing peptide.

Immunogène

synthetic peptide corresponding to amino acids 835-850 of SLIPR (rat homolog of MAGI-3) conjugated to KLH via a N-terminal added lysine residue.

Actions biochimiques/physiologiques

Membrane associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3) serves as a scaffold protein for frizzled-4 and Ltap . It helps to control the c-Jun N-terminal kinase (JNK) signaling cascade.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide as a preservative.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.