RAB1127

Mouse PAI-1 ELISA Kit

for cell culture supernatants, plasma, and serum samples

• Code UNSPSC : 41116158
• Nomenclature NACRES : NA.32

Propriétés

• Espèces réactives: mouse, human
• Technique(s): ELISA: suitable
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 80 pg/ml
• Conditions d'expédition: wet ice
• Température de stockage: −20°C

Description

Description générale

The PAI-1 (plasminogen activator inhibitor) gene is localized to human chromosome 7q22.1. Active form of PAI-1 is expressed in the blood and tissues. Platelets harbor both the active and latent forms of PAI-1.

This ELISA antibody pair detects mouse and human PAI-1.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Actions biochimiques/physiologiques

PAI-1 (plasminogen activator inhibitor) produced by platelets takes part in stabilizing blood clotting mechanism. PAI-1 prevents plasminogen activation during fibrinolysis. This might lead to the risk of cardiovascular disease. Elevated levels of PAI-1 has been observed in type 2 diabetes mellitus and serves the reason for reduced insulin sensitivity. PAI-1 stimulates the process of cellular senescence. PAI-1 regulation occurs through p53 dependent TGF-β (transforming growth factor-β) signalling. Studies also also predict that stress and depression might influence PAI-1 expression.

Autres remarques

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Informations sur la sécurité

• Pictogrammes: GHS05
• Mention d'avertissement: Warning
• Mentions de danger: H290
• Conseils de prudence: P234 - P390
• Classification des risques: Met. Corr. 1
• Code de la classe de stockage: 8A - Combustible corrosive hazardous materials
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable