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R6400

Sigma-Aldrich

Anti-phospho-Retinoblastoma (pSer807,811) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

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About This Item

Numéro MDL:
MFCD02097167
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous glycerol solution

Espèces réactives

rat, mouse, human

Technique(s)

western blot (chemiluminescent): 1:1,000 using human fibroblasts synchronized by serum deprivation

Numéro d'accès UniProt

P06400

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer807/pSer811)

Informations sur le gène

human ... RB1(5925)
mouse ... Rb1(19645)
rat ... Rb1(24708)

Catégories apparentées

Description générale

RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on human chromosome 13q14. It is a tumor-suppressor gene.

Spécificité

Recognizes phosphorylated Rb (Ser807/Ser811) and does not react with non-phosphorylated Rb. Does not react with Rb phosphorylated at other sites.

Immunogène

synthetic peptide corresponding to residues around phosphoserine 807/811 of the human retinoblastoma tumor suppressor protein (Rb), conjugated to KLH.

Application

Anti-phospho-Retinoblastoma (pSer807,811) has been used in western blotting.

Actions biochimiques/physiologiques

RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation.

Forme physique

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol.

Notes préparatoires

Purified using protein A and peptide affinity chromatography.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

A Parent-of-Origin Effect Impacts the Phenotype in Low Penetrance Retinoblastoma Families Segregating the c.1981C>T/p.Arg661Trp Mutation of RB1
Eloy P, et al.
PLoS Genetics, 12(2) (2016)
FUS/TLS is a novel mediator of androgen-dependent cell-cycle progression and prostate cancer growth
Brooke GN, et al.
Cancer Research, 71(3), 914-924 (2011)
Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development
Kashuba E and Mushtaq M
Experimental Oncology, 39(1), 12-16 (2017)
RB Loss Promotes Prostate Cancer Metastasis
Thangavel C, et al.
Cancer Research, 77(4), 982-995 (2017)
The Prognostic Value of the Immunohistochemical Expression of Phosphorylated RB and p16 Proteins in Association with Cyclin D1 and the p53 Pathway in a Large Cohort of Patients with Breast Cancer Treated with Taxane-based Adjuvant Chemotherapy
Gavressea T, et al.
Anticancer Research, 37(6), 2947-2957 (2017)

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