R3405

RP-107

≥98% (HPLC), solid

• Synonyme(s) : 7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine
• Formule empirique (notation de Hill): C₁₆H₁₇N₃O
• Numéro CAS: 496864-15-4
• Poids moléculaire : 267.33
• Numéro MDL: MFCD04973541
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824024

Propriétés

• Essai: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Solubilité: DMSO: >10 mg/mL; H₂O: insoluble
• Température de stockage: 2-8°C
• Chaîne SMILES: CCCCc1c([nH]c2nccnc12)-c3ccc(O)cc3
• InChI: 1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
• Clé InChI: PRIGRJPRGZCFAS-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel.

RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC₅₀ = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.

Caractéristiques et avantages

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves