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COO/COA

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P2495

Phalloidin, Coumarin Labeled

Name: Phalloidin, Coumarin Labeled
Brand: SIGMA

for actin detection

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About This Item

Formule empirique (notation de Hill):

C₆₂H₇₅N₁₁O₁₅S₂

Poids moléculaire :

1278.45

Code UNSPSC :

12352204

ID de substance PubChem :

329820138

Forme

solid

Solubilité

methanol: 1 mg/mL, clear, colorless to light yellow-green

Température de stockage

−20°C

InChI

1S/C62H75N11O15S2/c1-8-71(9-2)36-18-19-38-30(3)50(61(86)88-46(38)22-36)34-14-16-35(17-15-34)73-49(77)25-47(60(73)85)89-21-20-48(76)63-29-62(7,87)26-43-55(81)64-32(5)53(79)70-51(33(6)74)57(83)68-44-28-90-58-40(39-12-10-11-13-41(39)69-58)24-42(54(80)67-43)66-52(78)31(4)65-56(82)45-23-37(75)27-72(45)59(44)84/h10-19,22,31-33,37,42-45,47,51,69,74-75,87H,8-9,20-21,23-29H2,1-7H3,(H,63,76)(H,64,81)(H,65,82)(H,66,78)(H,67,80)(H,68,83)(H,70,79)/t31-,32-,33-,37-,42-,43-,44-,45-,47?,51+,62+/m0/s1

Clé InChI

GNSRKMXDGGXWDM-AZPABDIKSA-N

Application

A fluorescent phallotoxin which may be used to identify filamentous actin.

Notes préparatoires

From phalloidin isolated from Amanita phalloides mushrooms

Pictogrammes

GHS06

Mention d'avertissement

Danger

Mentions de danger

H300 + H310 + H330

Conseils de prudence

P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Classification des risques

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females.

V Padmanabhan et al.

Endocrinology, 151(2), 595-605 (2009-12-08)

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of reproductive-aged women and is exacerbated by obesity. Exposure of ewes to excess testosterone (T) from d 30-90 of gestation culminates in anovulation, functional hyperandrogenism, LH excess, and polyfollicular ovaries, features

ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells.

Shanhui Ren et al.

PLoS pathogens, 16(6), e1008514-e1008514 (2020-06-02)

Deoxyribonucleic acid (DNA) damage response (DDR) is the fundamental cellular response for maintaining genomic integrity and suppressing tumorigenesis. The activation of ataxia telangiectasia-mutated (ATM) kinase is central to DNA double-strand break (DSB) for maintaining host-genome integrity in mammalian cells. Oncolytic

Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth.

Steve Dos-Santos Carvalho et al.

eLife, 9 (2020-01-08)

Dynamic mechanical interactions between adhesion complexes and the cytoskeleton are essential for axon outgrowth and guidance. Whether planar cell polarity (PCP) proteins, which regulate cytoskeleton dynamics and appear necessary for some axon guidance, also mediate interactions with membrane adhesion is

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