Toutes les photos(1)

Key Documents

COO/COA

View All Documentation

P1123

PD 81,723

Name: PD 81,723
Brand: SIGMA

≥98% (HPLC), solid

Synonyme(s) :

(2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme

Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):

C₁₄H₁₂F₃NOS

Numéro CAS:

132861-87-1

Poids moléculaire :

299.31

Numéro MDL:

MFCD01321053

Code UNSPSC :

12352200

ID de substance PubChem :

329820073

Pureté

≥98% (HPLC)

Forme

solid

Conditions de stockage

protect from light
under inert gas

Couleur

yellow

Solubilité

DMSO: ~13 mg/mL
H₂O: insoluble

Température de stockage

−20°C

Chaîne SMILES

Cc1sc(N)c(c1C)C(=O)c2cccc(c2)C(F)(F)F

InChI

1S/C14H12F3NOS/c1-7-8(2)20-13(18)11(7)12(19)9-4-3-5-10(6-9)14(15,16)17/h3-6H,18H2,1-2H3

Clé InChI

KKDKAWKYGCUOGR-UHFFFAOYSA-N

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Actions biochimiques/physiologiques

Allosteric enhancer of A₁ adenosine receptors

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Enhancer and competitive allosteric modulation model for G-protein-coupled receptors.

Daniele Pietra et al.

Journal of theoretical biology, 267(4), 663-675 (2010-08-31)

A new mathematical model, referred to as Enhancer and Competitive Allosteric Modulator (ECAM) model, developed with the aim of quantitatively describing the interaction of an allosteric modulator with both enhancer and competitive properties towards G-protein-coupled receptors is described here. Model

Modulation of atrioventricular nodal function by metabolic and allosteric regulators of endogenous adenosine in guinea pig heart.

D M Dennis et al.

Circulation, 94(10), 2551-2559 (1996-11-15)

There has been increasing interest in the development of agents that utilize endogenous adenosine to exert their actions. We tested the hypothesis that substances that either potentiate the activity (allosteric enhancers) or increase the interstitial concentration (inhibitors of metabolism) of

Novel mitogenic effect of adenosine on coronary artery smooth muscle cells: role for the A1 adenosine receptor.

Jianzhong Shen et al.

Circulation research, 96(9), 982-990 (2005-04-16)

Adenosine is a vascular endothelial cell mitogen, but anti-mitogenic for aortic smooth muscle cells and fibroblasts when acting via the A2B adenosine receptor. However, we show that adenosine increases porcine coronary artery smooth muscle cell (CASMC) number, cellular DNA content

The role of the second and third extracellular loops of the adenosine A1 receptor in activation and allosteric modulation.

M C Peeters et al.

Biochemical pharmacology, 84(1), 76-87 (2012-03-28)

The adenosine A1 receptor is a member of the large membrane protein family that signals through G proteins, the G protein-coupled receptors (GPCRs). GPCRs consist of seven transmembrane domains connected by three intracellular and three extracellular loops. Their N-terminus is

Inhibition of muscarinic K+ current in guinea-pig atrial myocytes by PD 81,723, an allosteric enhancer of adenosine binding to A1 receptors.

B Brandts et al.

British journal of pharmacology, 121(6), 1217-1223 (1997-07-01)

1. PD 81,723 has been shown to enhance binding of adenosine to A1 receptors by stabilizing G protein-receptor coupling ('allosteric enhancement'). Evidence has been provided that in the perfused hearts and isolated atria PD 81,723 causes a sensitization to adenosine

Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique