O0884

Monoclonal Anti-Oncostatin M antibody produced in mouse

Name: Monoclonal Anti-Oncostatin M antibody produced in mouse
Brand: SIGMA

clone 17001, purified immunoglobulin, lyophilized powder

Synonyme(s) :

Anti-OSM

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A propos de cet article

UNSPSC Code:

51111800

EC Number:

202-739-6

NACRES:

NA.41

MDL number:

MFCD01092430

Conjugate:

unconjugated

Clone:

17001, monoclonal

Application:

ELISA (i), Neutral, WB

Citations:

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

17001, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

indirect ELISA: suitable, neutralization: suitable, western blot: suitable

isotype

IgG2a

UniProt accession no.

P13725

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... OSM(5008)

Catégories apparentées

Antibodies - Primary, Secondary & Recombinant Monoclonal

Antibodies by Application

Primary Antibodies

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1 of 4

Cet article	SAB1406204	SAB1402456	M2420
Sigma-Aldrich O0884 Monoclonal Anti-Oncostatin M antibody produced in mouse	Sigma-Aldrich SAB1406204 Anti-OSM antibody produced in mouse	Sigma-Aldrich SAB1402456 Monoclonal Anti-OSMR antibody produced in mouse	Sigma-Aldrich M2420 Monoclonal Anti-Monocyte Chemotactic Protein-1 antibody produced in mouse
species reactivity human	species reactivity human	species reactivity human	species reactivity human
clone 17001, monoclonal	clone polyclonal	clone 3E12, monoclonal	clone 24822, monoclonal
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
Gene Information human ... OSM(5008)	Gene Information human ... OSM(5008)	Gene Information human ... OSMR(9180)	Gene Information human ... CCL2(6347)
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source mouse	biological source mouse	biological source mouse

General description

Oncostatin M (OSM) is a growth-regulating cytokine produced by the activated T lymphocytes and macrophages. It has a pivotal role in stimulating the production of IL-6 in cultured human endothelial cells. It also facilitates the LDL receptor expression and its uptake by hepatoma cells. Further, OSM can induce synovial fibroblast-like cells to produce urokinase type plasminogen activator. Monoclonal anti-Oncostatin M antibody can be used for neutralizing the biological activity of rhOSM on the human TF-1 cell line. Mouse anti-Oncostatin M antibody reacts specifically with recombinant human OSM. The product has shown no cross-reactivity with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.

Immunogen

recombinant human OSM expressed in Escherichia coli.

Application

Monoclonal anti-Oncostatin M antibody can be used in western blotting and capture ELISA.

Biochem/physiol Actions

The antibody neutralizes the biological activity of recombinant human OSM. Does not cross-react with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline (PBS) with 5% trehalose.

Preparation Note

Purified using protein A.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Oncostatin M stimulates urokinase-type plasminogen activator activity in human synovial fibroblasts.

J A Hamilton et al.

Biochemical and biophysical research communications, 180(2), 652-659 (1991-10-31)

Cytokine regulation of synovial cell function has been considered to be involved in the pathogenesis of rheumatoid arthritis. Synoviocyte urokinase-type plasminogen activator (u-PA) expression may be relevant to the tissue remodelling, as well as to the cell migration and transformation

Regulation of IL-6 expression by oncostatin M.

T J Brown et al.

Journal of immunology (Baltimore, Md. : 1950), 147(7), 2175-2180 (1991-10-01)

Endothelial cells produce immunomodulatory cytokines in response to soluble mediators of inflammatory/immune reactions. We have previously demonstrated that the leukocyte-derived cytokine, oncostatin M (Onco M) can alter endothelial cell morphology, regeneration, and fibrinolytic activity in vitro. Here we demonstrate that

Oncostatin M up-regulates low density lipoprotein receptors in HepG2 cells by a novel mechanism.

R I Grove et al.

The Journal of biological chemistry, 266(27), 18194-18199 (1991-09-25)

Oncostatin M is a growth regulatory protein secreted by macrophages and activated T lymphocytes. In a hepatoma cell line (HepG2) the polypeptide very potently increased low density lipoprotein (LDL) uptake with an EC50 of 0.1-0.2 nM. The stimulation of LDL

Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin.

T Kitamura et al.

Journal of cellular physiology, 140(2), 323-334 (1989-08-01)

We have established a novel cell line, designated as TF-1, from a patient with erythroleukemia, which showed complete growth dependency on granulocyte-macrophage colony-stimulating factor (GM-CSF) or on interleukin-3 (IL-3) and carried a homogeneous chromosomal abnormality (54X). Erythropoietin (EPO) also sustained

Contenu apparenté

Data Sheet - O0884

Instructions

Numéro d'article de commerce international

Référence	GTIN
O0884-.5MG	04061832715056

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