M6053

Anti-Matrix Metalloproteinase-3, Propeptide Region antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• Synonyme(s) : Anti-MMP-3
• Numéro MDL: MFCD03455413
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 200
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous glycerol solution
• Poids mol.: antigen 59 kDa; antigen (pro-form) 57 kDa
• Espèces réactives: human
• Concentration: ~1 mg/mL
• Technique(s): western blot: 1:1000
• Numéro d'accès UniProt: P08254
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... MMP3(4314)

Description

Description générale

Matrix metalloproteinase-3 (MMP-3) is also known as stromelysin 1 and the gene encoding it is localized on human chromosome 11q22.3.

Spécificité

Reacts with reduced and to a lesser extent non-reduced MMP-3. The propeptide is shed after activation; therefore, the antibody recognizes the pro-form of MMP-3 and not the active forms. May be used to distinguish the latent from the active form of MMP-3. Recognizes Stromelysin-1 and Stromelysin-2, but not Stromelysin-3 or other MMP family members.

Immunogène

synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-3 (stromelysin-1).

Actions biochimiques/physiologiques

Matrix metalloproteinase-3 (MMP-3) plays an important role in cartilage degradation. It can act on a large number of substrates like type II, III, IV, IX and X collagens, laminin and fibronectin. MMP-3 can also activate other matrix metalloproteinases like MMP-1,-2 and -13. It has been associated with rheumatoid arthritis.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids