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GW22840

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Anti-ERP29 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

chicken

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

rat, human

Fabricant/nom de marque

Genway 15-288-22840

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NP_006808.1

Numéro d'accès UniProt

P30040

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ERP29(10961)

Immunogène

Immunogen Sequence: GI # 5803013, sequence 33-261
Recombinant endoplasmic reticulum protein 29 isoform 1

Application

Anti-ERP29 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Actions biochimiques/physiologiques

Endoplasmic reticulum protein 29 (ERp29) is a chaperone protein encoded by the ERP29 gene in humans. It is a novel factor that can drive mesenchymal-epithelial transition (MET) and induce cell growth arrest in MDA-MB-231 cells. It regulates MET and epithelial cell integrity in breast cancer cells. ERp29 is an endoplasmic reticulum (ER) stress-inducible protein and is highly expressed in several cancers and associated with resistance to oxidative and radiation stress. It may act as a potential biomarker for predicting nasopharyngeal carcinoma (NPC) response to radiotherapy.[1] The molecule facilitates processing and transport of proteins in the early secretory pathway and its over-expression significantly inhibits proliferation and suppresses tumorigenesis by modulating ER stress signaling and the mesenchymal-epithelial transition in breast cancer cells.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificats d'analyse (COA)

Lot/Batch Number
039K2165
029K2244
039K1878

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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Daohai Zhang et al.
The international journal of biochemistry & cell biology, 43(1), 33-36 (2010-10-06)
The endoplasmic reticulum protein 29 (ERp29) is a molecule that facilitates processing and transport of proteins in the early secretory pathway. Structural and functional analyses have suggested a biological role as a putative chaperone in the endoplasmic reticulum. The N-terminal
I Fon Bambang et al.
Laboratory investigation; a journal of technical methods and pathology, 89(11), 1229-1242 (2009-09-23)
Endoplasmic reticulum protein 29 (ERp29) is a novel endoplasmic reticulum (ER) secretion factor that facilitates the transport of secretory proteins in the early secretory pathway. Recently, it was found to be overexpressed in several cancers; however, little is known regarding
Ping Wu et al.
Oncology reports, 27(4), 987-994 (2011-12-14)
Radioresistance continues to be a major problem in the treatment of nasopharyngeal carcinoma (NPC). This study aimed to identify novel proteins associated with NPC
Lin Qi et al.
Medical oncology (Northwood, London, England), 29(2), 721-728 (2011-04-12)
ERp29 is an endoplasmic reticulum (ER) stress-inducible protein. It was found that ERp29 was highly expressed in several cancers and associated with resistance to oxidative and radiation stress, which may serve as a novel target for nasopharyngeal carcinoma (NPC) anticancer
I F Bambang et al.
Oncogene, 32(10), 1240-1251 (2012-05-01)
The epithelial-mesenchymal transition (EMT) correlates with disruption of cell-cell adhesion, loss of cell polarity and development of epithelial cell malignancy. Identifying novel molecules that inhibit EMT has profound potential for developing mechanism-based therapeutics. We previously demonstrated that the endoplasmic reticulum

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