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GW22346

Sigma-Aldrich

Anti-BCAS2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

chicken

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

mouse, rat, human

Fabricant/nom de marque

Genway 15-288-22346

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NP_005863.1

Numéro d'accès UniProt

O75934

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... BCAS2(10286)

Immunogène

Immunogen Sequence: GI # 5031653, sequence 1-225
Recombinant breast carcinoma amplified sequence 2

Application

Anti-BCAS2 antibody produced in chicken is suitable western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Actions biochimiques/physiologiques

Pre-mRNA-splicing factor SPF27 is a protein encoded by the BCAS2 gene in humans and is mapped to chromosome 1p13.3-21 region. It codes for a nuclear protein. BCAS2 is a novel gene up-regulated by amplification in human breast cancer cell lines. It acts as a transcriptional coactivator of estrogen receptor. It directly interacts with p53 to reduce p53 transcriptional activity and consistently decreases p53 protein in the absence of DNA damage. BCAS2 is a small nuclear protein (26kDa) and a novel negative regulator of p53. It is a potential molecular target for cancer therapy.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Consulter la Bibliothèque de documents

Ping-Chang Kuo et al.
Cancer research, 69(23), 8877-8885 (2009-11-12)
Breast cancer amplified sequence 2 (BCAS2) was reported previously as a transcriptional coactivator of estrogen receptor. Here, we report that BCAS2 directly interacts with p53 to reduce p53 transcriptional activity by mildly but consistently decreasing p53 protein in the absence
Nicolai Maass et al.
Cancer letters, 185(2), 219-223 (2002-08-10)
BCAS2 is a novel gene isolated from breast cancer cell line by differential display technique. Previously we reported that BCAS2 gene is localized on chromosome 1p13.3-21 and is up-regulated by gene amplification in breast cancer cell lines MCF-7 and BT-20.
K Nagasaki et al.
Cancer letters, 140(1-2), 219-226 (1999-07-14)
Screening for differentially expressed genes in cancer cell lines by the RNA differential display (DD) technique identified a novel mRNA that encodes a 26-kDa protein and is up-regulated in MCF-7 and BT-20 breast cancer cells. The predicted amino acid sequence

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