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GW21069

Sigma-Aldrich

Anti-CCL7 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-MARC, Anti-MCP3, Anti-Monocyte chemotactic protein 3, Anti-SCYA7, Anti-Small inducible cytokine A7

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About This Item

Numéro MDL:
MFCD01092423
Code UNSPSC :
12352203

Source biologique

chicken

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Fabricant/nom de marque

Genway 15-288-21069

Technique(s)

western blot: suitable

Numéro d'accès NCBI

NP_006264.2

Numéro d'accès UniProt

P80098

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CCL7(6354)

Immunogène

Immunogen Sequence: GI # 13435402, sequence 25-66
Recombinant chemokine (C-C motif) ligand 7

Application

Anti-CCL7 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Actions biochimiques/physiologiques

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine, earlier called as monocyte-specific chemokine 3 (MCP3). It regulates macrophage functions. It belongs to the monocyte chemotactic protein (MCP) subfamily of the CC chemokines and is produced by astrocytes. The CCL7 gene is mapped to chromosome 17 on subbands q11.2-q12. It induces production of gelatinase B and chemotaxis of monocytes. It is often produced by tumor cell lines and regulates protease secretion by macrophages. CCL7 production may contribute to invasion and metastasis of cancer cells. It may act as a novel target metastasis of colorectal cancer (CRC) and may be of potential clinical value for the prevention of hepatic recurrences. CCL7 may have a role in vascular pathology as well.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificats d'analyse (COA)

Lot/Batch Number
039K2076

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Nicole A Renner et al.
Journal of neurovirology, 17(2), 146-152 (2011-02-01)
Monocyte/macrophages and activated lymphocytes traffic through normal brain, and this trafficking is increased in inflammatory conditions such as HIV encephalitis (HIVE). HIVE is characterized in part by perivascular accumulations of macrophages. The earliest events in this process are poorly understood
Yong Beom Cho et al.
Oncology reports, 28(2), 689-694 (2012-05-23)
The main cause of death for colorectal cancer (CRC) patients is the development of metastatic lesions at sites distant from the primary tumor. Therefore, it is important to find biomarkers that are related to the metastasis and to study the
Marcella Maddaluno et al.
Atherosclerosis, 217(1), 113-119 (2011-05-04)
Monocyte chemotactic protein-3 (MCP-3), also known as CCL7, belongs to the monocyte chemotactic protein (MCP) subfamily of the CC chemokines that includes MCP-1/CCL2, MCP-2/CCL8, MCP-4/CCL13, and MCP-5/CCL12. Few studies have examined the role of MCP-3 in vascular pathologies such as
G Opdenakker et al.
Genomics, 21(2), 403-408 (1994-05-15)
Monocyte chemotactic proteins (MCPs) are chemokines involved in macrophage recruitment during inflammation and cancer. A full-size MCP-3 cDNA was used to isolate the functional human MCP-3 gene. Based on restriction analysis, subclones were selected and the MCP-3 gene sequence was
G Opdenakker et al.
Biochemical and biophysical research communications, 191(2), 535-542 (1993-03-15)
When human MG-63 osteosarcoma cells are triggered with IL-1 beta, they produce, among various other cytokines, also monocyte chemotactic proteins (MCPs). Homogeneous MCP-1, MCP-2 and MCP-3 were found to induce production of gelatinase B and chemotaxis of monocytes. Based on

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