F8304

Flavoxate hydrochloride

≥98% (HPLC), solid

• Synonyme(s) : 3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester hydrochloride, DW-61, Rec-7-0040
• Formule empirique (notation de Hill): C₂₄H₂₅NO₄ · HCl
• Numéro CAS: 3717-88-2
• Poids moléculaire : 427.92
• Numéro CE : 223-066-4
• Numéro MDL: MFCD00072099
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724484
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: solid
• Couleur: white
• Solubilité: H₂O: ~6.6 mg/mL
• Auteur: Johnson & Johnson
• Chaîne SMILES: Cl[H].CC1=C(Oc2c(cccc2C1=O)C(=O)OCCN3CCCCC3)c4ccccc4
• InChI: 1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H
• Clé InChI: XOEVKNFZUQEERE-UHFFFAOYSA-N
• Informations sur le gène: human ... PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE7A(5150) , PDE7B(27115) , PDE8A(5151) , PDE8B(8622)

Description

Actions biochimiques/physiologiques

Flavoxate, a flavone derivative and a tertiary-amine antimuscarinic possess antispasmodic properties. It is a strong smooth muscle relaxant that selectively acts on the pelvic region and is used in the symptomatic treatment of overactive bladder (OAB) and incontinence. Post-absorption in the gastrointestinal tract, flavoxate is localized in bladder, liver, and kidney tissues. It mediates the inhibition of phosphodiesterase (PDE) in the urinary bladder. Use of flavoxate aids pain relief in inflammatory disorders of the urinary tract.

L-type Ca²⁺ (Ca_v1.2) channel inhibitor

Caractéristiques et avantages

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H335
• Conseils de prudence: P261 - P264 - P270 - P271 - P301 + P312 - P304 + P340 + P312
• Classification des risques: Acute Tox. 4 Oral - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves