F7182
Fibroblast Activation Protein α human
recombinant, expressed in Sf21 cells, ≥95% (SDS-PAGE)
Synonyme(s) :
FAP, Seprase
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| À vous/Référence | Disponibilité | Prix |
|---|---|---|
10 μg | Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit. | 771,00 $ |
A propos de cet article
NACRES:
NA.54
UNSPSC Code:
12352204
Specific activity:
≥1800 units/μg protein
Assay:
≥95% (SDS-PAGE)
Recombinant:
expressed in Sf21 cells
771,00 $
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expressed in Sf21 cells
Quality Segment
assay
≥95% (SDS-PAGE)
form
solution
specific activity
≥1800 units/μg protein
impurities
≤1.0 EU/μg endotoxin
shipped in
dry ice
storage temp.
−70°C
General description
Fibroblast activation protein alpha (FAPa) is a type II transmembrane serine protease. It is present as a homodimeric integral protein with dipeptidyl peptidase IV like fold. It has an α/β-hydrolase domain and an eight-bladed β-propeller domain.[1] It is not expressed in normal tissue. It is only expressed by activated fibroblast in response to pathologic situations. It is expressed in several pathogenic sites including cancer, fibrosis, arthritis, wounding, or inflammation.[2]
Application
FAPa may be used to study the role in coordinating the stromal response to cancer, in angiogenesis, and modulation of the antitumor immune response.[2]
Biochem/physiol Actions
FAP is a Type II transmembrane serine protease which has substrate specificity for prolyl peptides bonds (Pro-Xaa). This endopeptidase cleaves gelatin and is believed to play a role in tissue remodeling, tumor invasion, and wound repair.
FAPα has in vitro dipeptidyl peptidase activity and collagenolytic activity. It cleaves N-terminal dipeptides from polypeptides and can degrade gelatin and type I collagen. It has also been reported that FAPa has a tumor suppressor activity.[1]
Physical form
Supplied as a solution in 25 mM Tris, 0.25 M NaCl and 20% (v/v) glycerol , pH 8.0
Other Notes
One unit will convert 1 picomole of benzyloxycarbonyl-Gly-Pro-7-amido-4-methylcoumarin (ZP-AMC) to Z-gly-Pro and 7-amino-4-methylcoumarin (AMC) per minute at pH 7.5 at 25°C.
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Cet article | |||
|---|---|---|---|
| specific activity ≥1800 units/μg protein | specific activity ≥10.2 pmol/min-g | specific activity - | specific activity - |
| assay ≥95% (SDS-PAGE) | assay ≥50% (SDS-PAGE) | assay - | assay - |
| form solution | form aqueous solution | form - | form buffered aqueous solution |
| recombinant expressed in Sf21 cells | recombinant expressed in baculovirus | recombinant - | recombinant - |
| storage temp. −70°C | storage temp. −70°C | storage temp. - | storage temp. −20°C |
| shipped in dry ice | shipped in dry ice | shipped in wet ice | shipped in dry ice |
Classe de stockage
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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