F4772
Monoclonal Anti-Cytokeratin Peptide 18−FITC antibody produced in mouse
clone CY-90, purified immunoglobulin, buffered aqueous solution
Synonyme(s) :
Monoclonal Anti-Cytokeratin Peptide 18
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About This Item
Produits recommandés
Source biologique
mouse
Conjugué
FITC conjugate
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
CY-90, monoclonal
Forme
buffered aqueous solution
Espèces réactives
wide range
Technique(s)
direct immunofluorescence: 1:100 using formalin-fixed, paraffin-embedded sections of human or animal tissues
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
Isotype
IgG1
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... KRT18(3875) , KRT18(3875)
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Catégories apparentées
Description générale
Broadly keratins are grouped into two types on the basis of their biochemical and immunological properties: Type II keratins are a family of basic proteins identified as K1 to K8, whereas type I keratins consists of K9 to K20, belong to the acidic group. It belongs to type I acrylic sub-family and is differentially expressed in various human tissues.
FITC Monoclonal Anti-Cytokeratin Peptide 18 is a purified mouse monoclonal antibody conjugated with fluorescein isothiocyanate (FITC) isomer I. Monoclonal Anti-Cytokeratin Peptide 18 (mouse IgG1 isotype) is derived from the CY-90 hybridoma produced by the fusion of mouse myeloma cells and splenocytes of immunized BALB/c mice. Cytokeratin 18 (CYK18) is a 45 kDa polypeptide, differentially expressed in various human tissues.
Immunogène
human epidermal carcinoma A-431 and MCF-7 human breast cancer cell lines.
Application
Monoclonal Anti-Cytokeratin Peptide 18 FITC antibody produced in mouse has been used in:
- direct immunofluorescent staining
- immunohistochemistry
- double immunofluorescence
- immunocytochemical and immuno?electron microscopic localization of keratins
Monoclonal Anti-Cytokeratin Peptide 18-FITC antibody:
- is suitable for immunohistochemistry to identify renal tubular epithelial cells in the extrarenal cells regeneration during acute renal failure
- is suitable for immunocytochemical and immuno-electron microscopic localisation of keratins in human materno-foetal interaction zone
- may be used for single or double labeling procedures
Actions biochimiques/physiologiques
Cytokeratins also called keratins (Ks) according to the new nomenclature system.These are known to be the major structural proteins of epithelial cells. It is heteropolymeric in nature i.e. in cells more than one keratin protein is always present. It belongs to type I acrylic sub-family and is differentially expressed in various human tissues. It maintains the structural integrity of extra-embryonic membrane epithelia. Broadly keratins are grouped into two types on the basis of their biochemical and immunological properties: Type II keratins are a family of basic proteins identified as K1 to K8, whereas type I keratins consists of K9 to K20, belong to the acidic group.
Monoclonal anti-cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. FITC Monoclonal Anti-Cytokeratin Peptide 18 is a chain specific antibody which can facilitate typing of normal, metaplastic and neoplastic cells. Cytokeratin 18 (CYK18) is a cytoskeletal protein associated with apoptosis. CK-18 is considered as a promising plasma biomarker to identify patients with HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome.
Forme physique
Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA with 15 mM sodium azide as a preservative.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Immunofluorescence confocal laser scanning microscopy and immuno-electron microscopic identification of keratins in human materno-foetal interaction zone
Ahenkorah J, et al.
Journal of Cellular and Molecular Medicine, 13(4), 735-748 (2009)
Immune microenvironment dynamics of HER2 overexpressing breast cancer under dual anti-HER2 blockade.
Sofia Batalha et al.
Frontiers in immunology, 14, 1267621-1267621 (2023-11-29)
The clinical prognosis of the HER2-overexpressing (HER2-OE) subtype of breast cancer (BC) is influenced by the immune infiltrate of the tumor. Specifically, monocytic cells, which are promoters of pro-tumoral immunosuppression, and NK cells, whose basal cytotoxic function may be enhanced
Sandeep Gupta et al.
Kidney international, 62(4), 1285-1290 (2002-09-18)
Recovery of renal function following acute tubular necrosis (ATN) is dependent on the replacement of necrotic tubular cells with functional tubular epithelium. The source of these new tubular cells is thought to be resident renal tubular cells. The discovery of
C Lampron et al.
The Journal of biological chemistry, 262(10), 4893-4898 (1987-04-05)
Differentiation of F9 embryonal carcinoma cells by retinoic acid treatment results in extraembryonic endoderm-like cells. The effects of this process on the protein composition of the intermediate filaments were studied by two-dimensional gel electrophoresis and by immunoblotting. By this approach
Tiziana Cubeddu et al.
Veterinary immunology and immunopathology, 189, 66-70 (2017-07-04)
Cathelicidins are well-characterized antimicrobial peptides (AMPs) that are present in significant amounts in mastitic milk. Neutrophils are believed to be the main producers of these AMPs, while the role of mammary epithelial cells (MECs) in their production and release is
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