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C6239

Sigma-Aldrich

Cinalukast

~98% (HPLC)

Synonyme(s) :

(E)-4-[[3-(2-(4-Cyclobutyl-2-thiazolyl)ethenyl)phenyl]amino]-2,2-diethyl-4-oxobutanoic acid, Ro 24-5913

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About This Item

Formule empirique (notation de Hill):
C23H28N2O3S
Numéro CAS:
128312-51-6
Poids moléculaire :
412.55
Numéro MDL:
MFCD00864778
Code UNSPSC :
12352202
ID de substance PubChem :
24724447
Nomenclature NACRES :
NA.77

Pureté

~98% (HPLC)

Forme

solid

Couleur

off-white

Solubilité

DMSO: >10 mg/mL
H2O: insoluble

Auteur

Roche

Température de stockage

2-8°C

Chaîne SMILES 

CCC(CC)(CC(=O)Nc1cccc(\C=C\c2nc(cs2)C3CCC3)c1)C(O)=O

InChI

1S/C23H28N2O3S/c1-3-23(4-2,22(27)28)14-20(26)24-18-10-5-7-16(13-18)11-12-21-25-19(15-29-21)17-8-6-9-17/h5,7,10-13,15,17H,3-4,6,8-9,14H2,1-2H3,(H,24,26)(H,27,28)/b12-11+

Clé InChI

BZMKNPGKXJAIDV-VAWYXSNFSA-N

Informations sur le gène

human ... CYSLTR1(10800)

Actions biochimiques/physiologiques

Specific CysLT1 leukotriene receptor antagonist.

Caractéristiques et avantages

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Studies of the combination of Ro 24-5913, a peptidoleukotriene antagonist, and Ro 24-4736, a PAF antagonist, in guinea pig and rat models of lung inflammation.
A F Welton et al.
Annals of the New York Academy of Sciences, 744, 274-288 (1994-11-15)
Michael Föller et al.
European journal of clinical investigation, 40(6), 534-540 (2010-05-12)
Fever and hyperthermia are frequently associated with anaemia. Under most clinical conditions, they are considered to be two mutually independent clinical consequences of a common cause. The present study explored the possibility that anaemia results from temperature-sensitive suicidal erythrocyte death
H Maehr et al.
Bioorganic & medicinal chemistry, 5(3), 493-496 (1997-03-01)
Structure optimization of the leukotriene D4 antagonist Ro24-5913 was attempted by combinatorial chemistry. Three segments in its N-succinyl-3-(2-thiazolylethenyl)anilide skeleton, designated as A, B, and C coincided with the thiazolyl, aniline, and N-acyl moieties, respectively, and were selected for variations in
G E Rovati et al.
Biochemical pharmacology, 44(7), 1411-1415 (1992-10-06)
We have identified and characterized two different subclasses of binding site for the novel peptido-leukotriene (LT) antagonist, [3H]ICI 198,615, in membranes from human lung parenchyma using a receptor-ligand assay. This novel compound is representative of a new class of LT
E Adelroth et al.
The Journal of allergy and clinical immunology, 99(2), 210-215 (1997-02-01)
The degree and duration of protection against exercise-induced bronchoconstriction afforded by three doses of a specific leukotriene D4 receptor antagonist, cinalukast, were assessed after an initial dosing and after 1 week of therapy. A placebo-controlled crossover study was performed in
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