C2979

Caspase 7 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, ≥1,500 units/mg protein

• Synonyme(s) : CMH-1, ICE-LAP3, Mch-3
• Numéro MDL: MFCD01865995
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Produit recombinant: expressed in E. coli
• Pureté: ≥95% (SDS-PAGE)
• Forme: buffered aqueous solution
• Activité spécifique: ≥1,500 units/mg protein
• Poids mol.: 56 kDa by immunoblotting
• Numéro d'accès UniProt: P55210
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Informations sur le gène: human ... CASP7(840)

Description

Actions biochimiques/physiologiques

Member of the CED-3 subfamily, the effector caspases, with an essential role in the apoptotic process. Upon activation, the zymogen is translocated to the mitochondrial and microsomal fractions. It is responsible for the cleavage of cellular substrates that precipitate the morphological changes of apoptosis.

Définition de l'unité

One unit will hydrolyze 1.0 nmol of Ac-Asp-Glu-Val-Asp-AFC per minute at pH 7.5 at 25 °C.

Forme physique

Solution in HEPES, NaCl, DTT and sucrose, without carrier protein

Remarque sur l'analyse

Migrates as two major polypeptides (20 kDa and 10 kDa) in immunoblotting. Two minor polypeptides derived from the large subunit are also present.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)