C1749
Monoclonal Anti-Polycystin-1 antibody produced in mouse
clone PKD46, tissue culture supernatant, buffered aqueous solution
Synonyme(s) :
Anti-PCKD, Anti-PKD1, Anti-Polycystic kidney disease 1 (autosomal dominant), Anti-Polycystic kidney disease-associated protein
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Conjugué
unconjugated
Forme d'anticorps
tissue culture supernatant
Type de produit anticorps
primary antibodies
Clone
PKD46, monoclonal
Forme
buffered aqueous solution
Poids mol.
antigen ~500 kDa
Espèces réactives
human, rat
Technique(s)
immunohistochemistry: 1:50-1:100 using human kidney sections
Isotype
IgM
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Informations sur le gène
human ... PKD1(5310)
Description générale
Monoclonal Anti-Polycystin-1 (mouse IgM isotype) is derived from the hybridoma PKD46 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human polycystin-1, conjugated to KLH. Polycystin-1 is composed of a large N-terminal extracellular region that contains several ligand-binding domains, multiple transmembrane domains and a cytoplasmic C-tail. It has a wide tissue distribution, with higher expression in the kidney, brain, liver, pancreas, heart and intestine.
Polycystin-1 is a protein encoded by the PKD1 gene in humans. It is also referred as PBP, Pc-1 and TRPP1. Polycystic kidney disease 1 (PKD1) gene is found on chromosome 16. It is a glycoprotein with multiple transmembrane domains and a cytoplasmic C-tail.
Immunogène
synthetic peptide corresponding to amino acids 4282-4300 of human polycystin-1, conjugated to KLH.
Application
Monoclonal Anti-Polycystin-1 antibody produced in mouse has been used in immunoblotting and immunohistochemistry.
Actions biochimiques/physiologiques
PKD1 protein is involved in the adhesion of protein-protein and protein-carbohydrate interactions in the extracellular compartment. The most common cause of autosomal dominant polycystic kidney disease (ADPKD) is due to mutation in the PKD1 gene. Alterations in single base substitutions within the coding sequence lead to missense or synonymous mutations in PKD1 gene. ADPKD caused by mutations in PKD1 gene is more severe than that caused by PKD2 gene mutations.
Polycystin-1 is associated with renal tubulogenesis and intracellular signaling pathways.
Forme physique
Solution containing 15 mM sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Rodney D Gilbert et al.
Pediatric nephrology (Berlin, Germany), 28(11), 2217-2220 (2013-04-30)
Dominant polycystic kidney disease is common and usually presents clinically in adulthood. Recessive polycystic kidney disease is much less common and frequently presents antenatally or in the neonatal period with severe renal involvement. These are usually thought of as clinically
Polycystin: new aspects of structure, function, and regulation
Wilson PD
Journal of the American Society of Nephrology, 12(4), 834-845 (2001)
Francisco J Gonzalez-Paredes et al.
Gene, 546(2), 243-249 (2014-06-08)
Autosomal dominant polycystic kidney disease is the most common human monogenic disorder and is caused by mutations in the PKD1 or PKD2 genes. Most patients with the disease present mutations in PKD1, and a considerable number of these alterations are
Jana Reiterová et al.
BMC nephrology, 14, 59-59 (2013-03-19)
Autosomal dominant polycystic kidney disease (ADPKD) is the most common form of inherited kidney disease that results in renal failure. ADPKD is a systemic disorder with cysts and connective tissue abnormalities involving many organs. ADPKD caused by mutations in PKD1
Cell, 81(2), 289-298 (1995-04-21)
Mutations in the PKD1 gene are the most common cause of autosomal dominant polycystic kidney disease (ADPKD). Other PKD1-like loci on chromosome 16 are approximately 97% identical to PKD1. To determine the authentic PKD1 sequence, we obtained the genomic sequence
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