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C0884

Sigma-Aldrich

Coenzyme B12

≥97.0%

Synonyme(s) :

5′-Deoxyadenosylcobalamine, Adenosyl cobalamine, Cobamamide, DMBC coenzyme

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25 MG
106,00 $
100 MG
151,00 $
250 MG
297,00 $
1 G
989,00 $

106,00 $

Disponible pour expédition le08 avril 2025Détails

Devis pour commande en gros
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Sélectionner une taille de conditionnement

Changer de vue
25 MG
106,00 $
100 MG
151,00 $
250 MG
297,00 $
1 G
989,00 $

About This Item

Formule empirique (notation de Hill) :
C72H100CoN18O17P
Numéro CAS:
13870-90-1
Poids moléculaire :
1579.58
Beilstein:
4122932
Numéro CE :
237-627-6
Numéro MDL:
MFCD00135609
Code UNSPSC :
12352205
ID de substance PubChem :
24892282
Nomenclature NACRES :
NA.79

106,00 $

Disponible pour expédition le08 avril 2025Détails

Devis pour commande en gros

Essai

≥97.0%

Forme

powder and chunks

Technique(s)

HPLC: suitable

Couleur

red to very dark red
very dark red-brown

Température de stockage

−20°C

Chaîne SMILES 

CC(CNC(=O)CCC1(C)C(CC(N)=O)C2N([Co+]C[C@H]3O[C@@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)C1=C(C)C6=NC(=CC7=NC(=C(C)C8=NC2(C)C(C)(CC(N)=O)C8CCC(N)=O)C(C)(CC(N)=O)C7CCC(N)=O)C(C)(C)C6CCC(N)=O)OP([O-])(=O)O[C@H]9[C@@H](O)[C@H](O[C@@H]9CO)n%10cnc%11cc(C)c(C)cc%10%11

InChI

1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-2/t31?,34?,35?,36?,37?,41-,52-,53-,56?,57+,59?,60?,61?,62?;4-,6-,7-,10+;/m11./s1

Clé InChI

ZIHHMGTYZOSFRC-PMDPKNCCSA-L

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Catégories apparentées

Description générale

Vitamin B12 cobalamin refers to a group of chemically-related cobalt containing molecules.[1] The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms.

Application

Coenzyme B12 has been used as a supplement for culturing plasmid variants in in vivo assay of yvrC-lacZ fusions.[2]

Actions biochimiques/physiologiques

Vitamin B12 cobalamin is involved in DNA synthesis and fatty acid synthesis.[1][3] It also plays a vital role as a coenzyme in the conversion of mitochondrial methylmalonyl co-enzyme A to succinyl co-enzyme A.[1]

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
WXBF5011V
0000175013
0000151495
0000151494
0000151496

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Radical carbon skeleton rearrangements: catalysis by coenzyme B12-dependent mutases.
Ruma Banerjee
Chemical reviews, 103(6), 2083-2094 (2003-06-12)
Coenzyme B12 riboswitches are widespread genetic control elements in prokaryotes
Nahvi A, et al.
Nucleic Acids Research, 32(1), 143-150 (2004)
Claire Chatelle et al.
ACS synthetic biology, 7(5), 1349-1358 (2018-04-11)
The ever-increasing complexity of synthetic gene networks and applications of synthetic biology requires precise and orthogonal gene expression systems. Of particular interest are systems responsive to light as they enable the control of gene expression dynamics with unprecedented resolution in
Radical catalysis in coenzyme B12-dependent isomerization (eliminating) reactions.
Tetsuo Toraya
Chemical reviews, 103(6), 2095-2127 (2003-06-12)
Gregory M Sandala et al.
Accounts of chemical research, 43(5), 642-651 (2010-02-09)
Enzymes accelerate chemical reactions with an exceptional selectivity that makes life itself possible. Understanding the factors responsible for this efficient catalysis is of utmost importance in our quest to harness the tremendous power of enzymes. Computational chemistry has emerged as
Afficher tous les articles scientifiques apparentés

Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. What is the pH stability of adenosylcobalamine?

    1 answer

    1. The pH stability of this product in solution has not been determined.

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