A9102

AH13205

≥98% (HPLC), oil

• Synonyme(s) : trans-2-(4-(1-Hydroxyhexyl)phenyl-5-oxocyclopentaneheptanoic acid
• Formule empirique (notation de Hill): C₂₄H₃₆O₄
• Numéro CAS: 148436-63-9
• Poids moléculaire : 388.54
• Numéro MDL: MFCD00797641
• Code UNSPSC : 12352200
• ID de substance PubChem : 329771031
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: oil
• Couleur: pale yellow
• Solubilité: DMSO: >10 mg/mL
• Auteur: GlaxoSmithKline
• Température de stockage: −20°C
• Chaîne SMILES: CCCCCC(O)c1ccc(cc1)[C@H]2CCC(=O)[C@@H]2CCCCCCC(O)=O
• InChI: 1S/C24H36O4/c1-2-3-6-10-22(25)19-14-12-18(13-15-19)20-16-17-23(26)21(20)9-7-4-5-8-11-24(27)28/h12-15,20-22,25H,2-11,16-17H2,1H3,(H,27,28)/t20-,21-,22?/m1/s1
• Clé InChI: XMQKDOCUWFCMEJ-JAZPPYFYSA-N

Description

Description générale

AH13205 is EP₂ prostanoid receptor agonist. There are five types of prostanoid receptors, which are classified based on sensitivity to the five naturally-occuring prostanoid ligand. The EP type of receptor is further divided into four subgroups – EP₁, EP₂, EP₃ and EP₄. EP₂ activation results in vascular, bronchial and reproductive smooth muscle relaxation.

Actions biochimiques/physiologiques

AH13205 is a selective, low potency agonist for the EP₂ receptor. AH13205 has been shown to compete with Prostaglandin E2 (PGE2) for binding, resulting in the displacement of PGE2 binding.

Caractéristiques et avantages

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)