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Principaux documents

COO/COA

A5229

Agitoxin-1

Name: Agitoxin-1
Brand: SIGMA

recombinant, expressed in E. coli, ≥98% (HPLC), lyophilized powder

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About This Item

Numéro MDL:

MFCD07370216

Code UNSPSC :

12352200

Pureté

≥98% (HPLC)

Forme

lyophilized powder

Poids mol.

4021 Da

Solubilité

H₂O: soluble
aqueous buffer: soluble

Température de stockage

−20°C

Amino Acid Sequence

Gly-Val-Pro-Ile-Asn-Val-Lys-Cys-Thr-Gly-Ser-Pro-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Ile-Asn-Gly-Lys-Cys-His-Cys-Thr-Pro-Lys

Application

Agitoxin-1 is a potent blocker of the Shakervoltage-gated K⁺ channels. Agitoxin has also been used to improve multi-dimensional NMR of proteins.

Actions biochimiques/physiologiques

Toxin found in the venom of the scorpion Leiurus quinquestriatus hebraeus. Potent blocker of the Shakervoltage-gated K⁺ channels as well as the mammalian homologues of Shaker

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Fast multi-dimensional NMR of proteins.

Eriks Kupce et al.

Journal of biomolecular NMR, 25(4), 349-354 (2003-05-27)

Three-dimensional HNCO and HNCA subspectra from a small protein (agitoxin, 4 kDa, enriched in carbon-13 and nitrogen-15), have been obtained by direct frequency-domain excitation of selected carbon and nitrogen sites. This new technique applies an array of several simultaneous soft

Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom.

M L Garcia et al.

Biochemistry, 33(22), 6834-6839 (1994-06-07)

Three new toxins from the venom of the scorpion Leiurus quinquestriatus var. hebraeus have been identified on the basis of their ability to block the Shaker K+ channel. These toxins have been purified using HPLC techniques and characterized as 38

Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system and enhancing acetylcholine release.

G Suarez-Kurtz et al.

The Journal of pharmacology and experimental therapeutics, 289(3), 1517-1522 (1999-05-21)

Potent and selective peptidyl blockers of the Shaker-type (Kv1) voltage-gated potassium channels were used to determine the role of these channels in regulating the spontaneous motility of smooth muscle preparations. Margatoxin (MgTX), kaliotoxin, and agitoxin-2 at 1 to 10 nM

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