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A4626

Sigma-Aldrich

1-Acetyl-2-phenylhydrazine

≥98%

Synonyme(s) :

N-Acetyl-N′-phenylhydrazine, acetylphenylhydrazine

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About This Item

Formule linéaire :
CH3CONHNHC6H5
Numéro CAS:
114-83-0
Poids moléculaire :
150.18
Numéro CE :
204-055-3
Numéro MDL:
MFCD00008672
Code UNSPSC :
12352127
ID de substance PubChem :
24890888
Nomenclature NACRES :
NA.25

Pureté

≥98%

Forme

(Powder with Chunk(s) or Crystals with Chunk(s))

Pf

128-131 °C (lit.)

Chaîne SMILES 

CC(=O)NNc1ccccc1

InChI

1S/C8H10N2O/c1-7(11)9-10-8-5-3-2-4-6-8/h2-6,10H,1H3,(H,9,11)

Clé InChI

UICBCXONCUFSOI-UHFFFAOYSA-N

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Application

1-Acetyl-2-phenylhydrazine (AcPhHZ) which reacts with oxyhaemoglobin to form free radicals may be used to induce haemolytic anaemia for studies of the hematopoietic system.

Actions biochimiques/physiologiques

1-Acetyl-2-phenylhydrazine (AcPhHZ) is a vascular tumor initiator used in experimental animal model.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificats d'analyse (COA)

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2,4-Dinitrophenylhydrazine reagent grade, 97%

Sigma-Aldrich

D199303

2,4-Dinitrophenylhydrazine

Y Fujii et al.
Journal of electron microscopy, 46(6), 477-484 (1997-01-01)
A new 'tissue-stamp culture' method was developed for stamping proliferating erythroblasts of mouse spleens on collagen-coated coverslips after inducing haemolytic anaemia by administration of 1-acetyl-2-phenylhydrazine, and then adherent splenic cells were cultured for a few days. We could obtain many
R Olinescu et al.
Research communications in chemical pathology and pharmacology, 84(1), 27-34 (1994-04-01)
Following the administration of phenylhydrazine, cadmium chloride and ethanol to rats there was a marked increase in the concentration of liver lipid peroxides and a sharp decline in GSH levels. The oxidative stress generated by the action of these toxic
H Ohno et al.
Fundamental and applied toxicology : official journal of the Society of Toxicology, 20(2), 141-146 (1993-02-01)
DQ-2511, a new anti-ulcer drug, was administered to beagle dogs for 4 weeks to investigate the mechanism whereby this drug induced hemolytic anemia and its reversibility in comparison with beta-acetylphenylhydrazine. Hemolytic anemia accompanied by an increase in the number of
Simonetta Croci et al.
Anticancer research, 22(5), 2903-2906 (2003-01-18)
The end result of our research would be the development of a new diagnostic technique that could be used as a screening test, starting from a simple blood collection, a common procedure without any risk to the subject. Red blood
Y Manabe et al.
The Journal of toxicological sciences, 25(3), 161-165 (2000-09-15)
In this study, a new simple method to measure erythrocyte fragility with stirring of diluted blood (stirring method) was introduced and evaluated with anemic rats given beta-acetylphenylhydrazine (APHZ) or clofibrate. APHZ at a dose of 40 mg/kg caused significant decreases
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