This IC50 for this compound has not been determined. A brief search of the literature shows a fairly broad range in various organisms and/or tissue types. A more thorough literature search would be advised.
A3085
5-(N-Ethyl-N-isopropyl)amiloride
≥98% (TLC), powder, Na⁺/H⁺ antiport inhibitor
Synonyme(s) :
EIPA
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| Taille/Référence | Disponibilité | Prix |
|---|---|---|
25 mg | Vérifier la disponibilité des articles du panier | 340,00 $ |
100 mg | Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit. | 1 160,00 $ |
A propos de cet article
Formule empirique (notation de Hill) :
C11H18ClN7O
Numéro CAS:
Poids moléculaire :
299.76
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
powder
Service technique
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Laissez-nous vous aiderNom du produit
5-(N-Ethyl-N-isopropyl)amiloride,
biological source
synthetic
Quality Segment
assay
≥98% (TLC)
form
powder
mp
202-205 °C (lit.)
solubility
methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow
storage temp.
2-8°C
SMILES string
CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
InChI
1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChI key
QDERNBXNXJCIQK-UHFFFAOYSA-N
Gene Information
human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784), Slc9a4(24785)
Application
5-(N-Ethyl-N-isopropyl)amiloride has been used:
- as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cell
- in Pluronic F-127 stock solution for Drosophila larval live-imaging
- in choline chloride solution as an experimental perfusate, to study the effect of Na+/H+ inhibition on jejunal loop perfusion in vivo
Biochem/physiol Actions
Selective blocker of Na+/H+ antiport
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Cet article | |||
|---|---|---|---|
| description - | description ≥98% (TLC), powder | description - | description - |
| assay ≥98% (TLC) | assay ≥98% (TLC) | assay - | assay - |
| form powder | form powder | form powder | form powder |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow | solubility methanol: 9.80-10.20 mg/mL, clear, pale yellow to yellow | solubility - | solubility - |
| Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553) | Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340) | Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548) | Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553) |
Mot-clé
Warning
Codes de danger
Mentions de précaution
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organes cibles
Respiratory system
Classe de stockage
11 - Combustible Solids
Que se passe-t-il ?
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
EPI (équipement de protection individuelle)
dust mask type N95 (US), Eyeshields, Gloves
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¿Cuál es el IC50 de esta sustancia?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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How can I store a solution of 5-(N-Ethyl-N-isopropyl)amiloride, Product A3085?
1 answer-
We do not have solution stability information for 5-(N-Ethyl-N-isopropyl)amiloride. The product is sensitive to light, particularly in solution. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
Helpful?
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What concentration of Product A3085, 5-(N-Ethyl-N-isopropyl)amiloride, should I use in my experiment?
1 answer-
We have the following references for the use of 5-(N-Ethyl-N-isopropyl)amiloride. A review article mentions the use of EIPA at 1 micromolar to probe Na+ channels in rat alveolar epithelial cells; see: Matalon, S., et al., Biophysical and molecular properties of amiloride-inhibitable Na+ channels in alveolar epithelial cells. Am. J. Physiol., 271, L1-L22 (1996). A study of the effects of EIPA on infarction in isolated rabbit hearts and cardiomyocytes has been reported; see: Sato, H., et al., The mechanism of protection from 5 (N-ethyl-N-isopropyl)amiloride differs from that of ischemic preconditioning in rabbit heart. Basic Res. Cardiol., 92, 339-350 (1997).
Helpful?
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What can I use to make a solution of 5-(N-Ethyl-N-isopropyl)amiloride, Product A3085?
1 answer-
We test solubility of 5-(N-Ethyl-N-isopropyl)amiloride in methanol (10 mg/mL), yielding a clear yellow solution. It is also soluble in DMSO, and in dilute aqueous acid. It is insoluble in water.
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