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A281

Sigma-Aldrich

Apigenin

solid

Synonyme(s) :

4′,5,7-Trihydroxyflavone, 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone

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About This Item

Formule empirique (notation de Hill):
C15H10O5
Numéro CAS:
520-36-5
Poids moléculaire :
270.24
Numéro Beilstein :
262620
Numéro CE :
208-292-3
Numéro MDL:
MFCD00006831
Code UNSPSC :
12171500

Forme

solid

Couleur

yellow to green

Pf

>300 °C (lit.)

Solubilité

DMSO: 27 mg/mL
H2O: insoluble

Chaîne SMILES 

Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2

InChI

1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

Clé InChI

KZNIFHPLKGYRTM-UHFFFAOYSA-N

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Actions biochimiques/physiologiques

A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.

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Iris L K Wong et al.
Antimicrobial agents and chemotherapy, 51(3), 930-940 (2006-12-30)
Drug resistance by overexpression of ATP-binding cassette (ABC) transporters is an impediment in the treatment of leishmaniasis. Flavonoids are known to reverse multidrug resistance (MDR) in Leishmania and mammalian cancers by inhibiting ABC transporters. Here, we found that synthetic flavonoid
Heshu Lu et al.
Journal of medicinal chemistry, 48(3), 737-743 (2005-02-04)
Cyclin-dependent kinases (CDKs) play a central role in cell cycle control, apoptosis, transcription, and neuronal functions. They are important targets for the design of drugs with antimitotic or antineurodegenerative effects. CDK4 and CDK6 form a subfamily among the CDKs in
Gao-Jun Fan et al.
Bioorganic & medicinal chemistry letters, 17(24), 6720-6722 (2007-10-30)
The bioassay-guided purification of ether extracts of Alpinia officinarum led to the isolation of two new compounds 6-hydroxy-1,7-diphenyl-4-en-3-heptanone (1) and 6-(2-hydroxy-phenyl)-4-methoxy-2-pyrone (4) as well as three known compounds 1,7-diphenyl-4-en-3-heptanone (2), 1,7-diphenyl-5-methoxy-3-heptanone (3), and apigenin (5). Their structures were established on
Kee Dong Yoon et al.
Journal of natural products, 70(12), 2029-2032 (2007-11-13)
Three new flavonoid glycosides ( 1- 3), 11-hydroxyhainanolidol ( 4), and a new dibenzylbutyrolactone lignan glycoside ( 5) were isolated from the aerial parts of Cephalotaxus koreana Nakai, along with 19 known flavonoids. The structures of the new compounds were
Veljko Veljkovic et al.
Bioorganic & medicinal chemistry letters, 17(5), 1226-1232 (2006-12-27)
Flavonoid compounds represent an important natural source of antiretrovirals for AIDS therapy due to their significant anti-HIV-1 activity and low toxicity. Here we propose a simple theoretical criterion to discriminate active from inactive flavonoids that is suitable for rapid in
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