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482R-1

Sigma-Aldrich

p63 (EP174) Rabbit Monoclonal Primary Antibody

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1 VIAL
233,00 $
1 ML
233,00 $
1 VIAL
429,00 $
0.1 ML
429,00 $
1 VIAL
471,00 $
7 ML
471,00 $
1 VIAL
941,00 $
25 ML
1 400,00 $
25 ML
1 400,00 $
1 ML
1 630,00 $
1 VIAL
1 630,00 $

233,00 $

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Toutes les photos(3)

Sélectionner une taille de conditionnement

Changer de vue
1 VIAL
233,00 $
1 ML
233,00 $
1 VIAL
429,00 $
0.1 ML
429,00 $
1 VIAL
471,00 $
7 ML
471,00 $
1 VIAL
941,00 $
25 ML
1 400,00 $
25 ML
1 400,00 $
1 ML
1 630,00 $
1 VIAL
1 630,00 $

About This Item

Code UNSPSC :
12352203

233,00 $

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Devis pour commande en gros

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP174

Description

For In Vitro Diagnostic Use in Select Regions

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (482R-14)
vial of 0.1 mL concentrate, Research Use Only (482R-14-RUO)
vial of 0.5 mL concentrate (482R-15)
vial of 1.0 mL concentrate (482R-16)
vial of 1.0 mL concentrate, Research Use Only (482R-16-RUO)
vial of 1.0 mL pre-dilute ready-to-use, Research Use Only (482R-17-RUO)
vial of 1.0 mL pre-dilute, ready to use (482R-17)
vial of 25.0 mL pre-dilute ready-to-use (482R-10)
vial of 25.0 mL pre-dilute ready-to-use, Research Use Only (482R-10-RUO)
vial of 7.0 mL pre-dilute, ready to use (482R-18)
vial of 7.0 mL pre-dilute, ready to use, Research Use Only (482R-18-RUO)

Fabricant/nom de marque

Cell Marque

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (1:100-1:200 (concentrated))

Isotype

IgG

Contrôle

lung (squamous cell carcinoma), prostate

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

nuclear

Description générale

p63 is a transcription factor that regulates many cell activities, including cell proliferation, maintenance, differentiation, adhesion, and apoptosis.1 It has been found to be a sensitive and specific marker of myoepithelial and basal cell populations in prostate, breast, skin, and salivary gland. Additionally, p63 has also demonstrated immunohistochemical utility in identifying benign and malignant breast lesions.2 In prostatic carcinomas, it can also be used to recognize benign glands adjacent to malignant glands.3 p63 can also be used to differentiate adenocarcinoma of the lungs, where it is usually negative, from squamous cell carcinoma, which can be useful for advanced stages of the carcinoma where surgery is no longer an option.4

Qualité

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

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Autres remarques

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Ricardo Camilo et al.
Human pathology, 37(5), 542-546 (2006-05-02)
In this study, we sought to validate the importance of p63, CK5/CK6, CK7, and surfactant-A (SP-A) to classify 42 non-small cell lung cancers in autopsy and surgical resection specimens and to study the usefulness of these markers in distinguishing between
D Stefanou et al.
Histology and histopathology, 19(2), 465-471 (2004-03-17)
The p63 gene encodes six protein isoforms. The transactivating isoforms have similar actions with p53, while the N-isoforms inhibit transcription activation by p53 and transactivating isoforms. p63 is expressed in stratified epithelia and in basal cells of the prostate and
Zhong Jiang et al.
American journal of clinical pathology, 123(2), 231-236 (2005-04-22)
We assessed the usefulness of immunohistochemical analysis with a 3-antibody cocktail (alpha-methylacyl coenzyme A racemase [AMACR, or P504S], 34betaE12, p63) and a double-chromogen reaction for detection of limited prostate cancer in 138 needle biopsy specimens, including 82 with small foci
A Yang et al.
Molecular cell, 2(3), 305-316 (1998-10-17)
We describe the cloning of p63, a gene at chromosome 3q27-29 that bears strong homology to the tumor suppressor p53 and to the related gene, p73. p63 was detected in a variety of human and mouse tissues, including proliferating basal

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