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460R-1

Sigma-Aldrich

Heat Shock Protein 70 (EP377) Rabbit Monoclonal Primary Antibody

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1 ML
289,00 $
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289,00 $
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320,00 $
1 VIAL
320,00 $
7 ML
732,00 $
1 VIAL
732,00 $
0.5 ML
893,00 $
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1 ML
1 390,00 $
1 VIAL
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289,00 $


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Sélectionner une taille de conditionnement

Changer de vue
1 ML
289,00 $
1 ML
289,00 $
0.1 ML
320,00 $
1 VIAL
320,00 $
7 ML
732,00 $
1 VIAL
732,00 $
0.5 ML
893,00 $
1 VIAL
893,00 $
1 ML
1 390,00 $
1 VIAL
1 390,00 $

About This Item

Code UNSPSC :
12352203

289,00 $


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Devis pour commande en gros

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP377, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (460R-14)
vial of 0.1 mL concentrate Research Use Only (460R-14-RUO)
vial of 0.5 mL concentrate (460R-15)
vial of 1.0 mL concentrate (460R-16)
vial of 1.0 mL concentrate Research Use Only (460R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (460R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (460R-17)
vial of 7.0 mL pre-dilute ready-to-use (460R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (460R-18-RUO)

Fabricant/nom de marque

Cell Marque®

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

Isotype

IgG

Contrôle

hepatocellular carcinoma

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic, nuclear

Informations sur le gène

human ... HSPA1A(3303)

Description générale

The Heat Shock Protein 70 family of highly conserved chaperone proteins increase in expression upon exposure to stress factors such as temperature shock, hypoxia, oxidative stress, and pH change.[1] This promotes cell survival by repairing misfolded proteins and preventing protein aggregates, among other functions.[1] Likewise, tumor cells can use this mechanism to confer a survival advantage as demonstrated in Heat Shock Protein 70 overexpression in hepatocellular carcinoma.[2][3][4][5][1]

Qualité

United States - IVD
European Union - IVD
Japan - RUO

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

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Autres remarques

For Technical Service please contact: 800-665-7284 or email: [email protected]

Informations légales

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2


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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Maureen E Murphy
Carcinogenesis, 34(6), 1181-1188 (2013-04-09)
The HSP70 family of heat shock proteins consists of molecular chaperones of approximately 70kDa in size that serve critical roles in protein homeostasis. These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent
Eun Shin et al.
Journal of hepato-biliary-pancreatic sciences, 18(4), 544-550 (2011-01-15)
Heat shock protein 70 (HSP70) and glutamine synthetase (GS) have been proposed to be promising markers for the differentiation of malignant and benign hepatocellular lesions. The aim of this study was to investigate the clinicopathological significance of the expression of
Luca Di Tommaso et al.
Journal of hepatology, 50(4), 746-754 (2009-02-24)
Liver biopsy for hepatocellular carcinoma (HCC) detection is largely restricted to small hepatocellular lesions, which are often morphologically challenging, requiring careful distinction between dysplastic nodules (high-grade) and well-differentiated HCC. We investigated the diagnostic accuracy of a panel of markers (HSP70
Stephen M Lagana et al.
Applied immunohistochemistry & molecular morphology : AIMM, 21(2), 170-176 (2012-08-24)
The pathologic distinction between hepatocellular carcinoma (HCC) and hepatocellular adenoma (HCA) is sometimes problematic due to histologic overlap between the 2 entities, a problem amplified on small biopsy specimens. Several recently characterized immunohistochemical markers such as glypican-3 (GPC-3), heat-shock protein-70
Thuy B Nguyen et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 29(3), 283-292 (2016-01-16)
Well-differentiated hepatocellular carcinoma can mimic high-grade dysplastic nodule in cirrhotic liver and hepatocellular adenoma in non-cirrhotic liver. This study evaluates the efficacy of combined use of heat-shock protein 70 (HSP70), glutamine synthetase (GS) and glypican-3 in this setting. Immunohistochemistry for

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