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338R-2

Sigma-Aldrich

TdT (EP266) Rabbit Monoclonal Primary Antibody

Synonyme(s) :

Terminal Deoxynucleotidyl Transferase

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About This Item

Code UNSPSC :
12352203

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP266, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (338R-24)
vial of 0.1 mL concentrate Research Use Only (338R-24-RUO)
vial of 0.5 mL concentrate (338R-25)
vial of 1.0 mL concentrate (338R-26)
vial of 1.0 mL concentrate Research Use Only (338R-26-RUO)
vial of 1.0 mL pre-dilute Research Use Only (338R-27-RUO)
vial of 1.0 mL pre-dilute ready-to-use (338R-27)
vial of 7.0 mL pre-dilute ready-to-use (338R-28)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (338R-28-RUO)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)

Isotype

IgG

Contrôle

thymus

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

nuclear

Informations sur le gène

human ... DNTT(1791)

Description générale

TdT (terminal deoxynucleotidyl transferase) is a template-independent DNA polymerase that adds nucleotides randomly to single-stranded DNA. This randomization plays a role in acquired immunity by increasing antigen receptor diversity and aiding in the generation of immunoglobulins and T cell antigen receptors. TdT expression is characteristic of lymphoid progenitor cells in thymus and tonsils. Anti-TdT is a useful marker for lymphoblastic lymphomas and has been observed in some cases of acute myeloid leukemia.

Qualité


IVD
IVD
IVD
RUO

Liaison

TdT Positive Control Slides, Product No. 338S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections)

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

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Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Edward A Motea et al.
Biochimica et biophysica acta, 1804(5), 1151-1166 (2009-07-15)
Nearly every DNA polymerase characterized to date exclusively catalyzes the incorporation of mononucleotides into a growing primer using a DNA or RNA template as a guide to direct each incorporation event. There is, however, one unique DNA polymerase designated terminal
James A Strauchen et al.
International journal of surgical pathology, 11(1), 21-24 (2003-02-25)
To investigate the occurrence of lymphoid progenitor cells in human tonsils, we studied tonsils from children and adults by immunohistochemistry by using a panel of antibodies to antigens associated with lymphoid progenitor cells, including terminal deoxynucleotidyl transferase (TdT), CD10 (CALLA)
J Suzumiya et al.
The Journal of pathology, 182(1), 86-91 (1997-05-01)
Terminal deoxynucleotidyl transferase (TdT) is a DNA polymerase located in the cell nucleus which catalyses the polymerization of deoxynucleotides at the 3'hydroxyl ends of oligo- or polydeoxynucleotide initiators without a template. TdT is known as a useful marker for the
D A Arber et al.
American journal of clinical pathology, 106(4), 462-468 (1996-10-01)
The immunohistochemical evaluation of acute leukemia specimens has been limited in the past due of the inability to detect many lineage-related antigens in paraffin sections. With the improvement in immunohistochemical methods as well as the introduction of new antibodies, these

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