M1000000

Methotrexate

European Pharmacopoeia (EP) Reference Standard

• Synonyme(s) : (+)-Amethopterin, 4-Amino-10-methylfolic acid, 4-Amino-N¹⁰-methylpteroyl-L-glutamic acid, Antifolan, MTX, Methylaminopterin
• Formule empirique (notation de Hill) : C₂₀H₂₂N₈O₅
• Numéro CAS: 59-05-2
• Poids moléculaire : 454.44
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329817845
• MDL number: MFCD00064370
• Beilstein/REAXYS Number: 70669

Propriétés

• grade: pharmaceutical primary standard
• API family: methotrexate
• manufacturer/tradename: EDQM
• application(s): pharmaceutical; pharmaceutical (small molecule)
• format: neat
• SMILES string: CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
• InChI key: FBOZXECLQNJBKD-ZDUSSCGKSA-N
• Gene Information: human ... DHFR(1719)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Methotrexate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mot-clé: Danger
• Codes de danger: H301,H341,H360D,H372
• Mentions de précaution: P202 - P260 - P264 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Muta. 2 - Repr. 1B - STOT RE 1
• Organes cibles: Liver,Bone marrow
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable