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28514

Sigma-Aldrich

Methylene Blue hydrate

≥95% (calc. to the dried substance)

Synonyme(s) :

Basic Blue 9 monohydrate ; Methylene Blue (hydrate)

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About This Item

Formule empirique (notation de Hill):
C16H18ClN3S · xH2O
Numéro CAS:
122965-43-9
Poids moléculaire :
319.85 (anhydrous basis)
Numéro Beilstein :
3599847
Numéro CE :
200-515-2
Numéro MDL:
MFCD00150006
Code UNSPSC :
12171500
ID de substance PubChem :
329753217
Nomenclature NACRES :
MA.02

Niveau de qualité

200

Pureté

≥95% (calc. to the dried substance)

Forme

powder

Impuretés

≤1% insoluble in ethanol

Perte

≤22% loss on drying, 105 °C

Couleur

very dark green

Solubilité

ethanol: insoluble ≤1%

Application(s)

diagnostic assay manufacturing
hematology
histology

Température de stockage

room temp

Chaîne SMILES 

O.[Cl-].CN(C)c1ccc2N=C3C=C\C(C=C3Sc2c1)=[N+](/C)C

InChI

1S/C16H18N3S.ClH.H2O/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;;/h5-10H,1-4H3;1H;1H2/q+1;;/p-1

Clé InChI

WQVSELLRAGBDLX-UHFFFAOYSA-M

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Catégories apparentées

Description générale

Methylene blue is bis(dimethylamino)phenothiazine hydrochloride (tetramethylthionine),
C16H18N3SCl. It is a major basic histological dye in pharmacology and microbiology. This heterocyclic aromatic chemical appears as a dark green solid powder, changing to blue in an aqueous solution. Methylene blue is tested for histological and and bacteriological staining, and as a constituent of Wright’s blood stain.

Application

Methylene blue is widely used in several routine staining applications including Mallory’s phloxine-methylene blue on paraffin sections of tissue fixed in Zenker’s fluid for nuclear staining and bacterial staining in milk. It is also suitable for manufacturing the polychrome methylene blue used in the preparation of Romanowsky stains.Methylene Blue hydrate has also been used:
  • in the preparation of methylene blue (MB) solution
  • to stain zymograms -to label the injection site in the tissue slices
  • to pre-treat mice via oral gavage to study its effects on noise-induced hearing loss

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCL3071
BCCM2511
BCCK2722
BCCH5622
BCCF5228

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Consulter la Bibliothèque de documents

Paul J Derry et al.
Nanoscale, 11(22), 10791-10807 (2019-05-28)
Previously, our group reported on the promising efficacy of poly(ethylene glycol)-hydrophilic carbon clusters (PEG-HCCs) to work as broadly active and high capacity antioxidants in brain ischemia and injury models including stroke and traumatic brain injury coupled with hemorrhagic shock. PEG-HCCs
Wei Guo et al.
Acta pharmacologica Sinica, 41(3), 423-431 (2019-06-15)
Indoleamine 2,3-dioxygenase 1 (IDO1) is emerging as a promising therapeutic target for the treatment of malignant tumors characterized by dysregulated tryptophan metabolism. However, the antitumor efficacy of existing small-molecule IDO1 inhibitors is still unsatisfactory, and the underlying mechanism remains largely

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