MABS494

Anti-phospho MEKK5, (Thr845), clone PA214 Antibody

clone PA214, from rabbit

• Synonyme(s) : MEKK5, Apoptosis signal-regulating kinase 1, MAPK/ERK kinase kinase 5, ASK-1, MEK kinase 5, MEKK 5, ASK1
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: purified antibody
• Type de produit anticorps: primary antibodies
• Clone: PA214, monoclonal
• Espèces réactives: human, mouse
• Technique(s): western blot: suitable
• Numéro d'accès NCBI: NP_005914
• Numéro d'accès UniProt: Q99683
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: phosphorylation (pThr845)
• Informations sur le gène: human ... MAP3K5(4217)

Description

Description générale

MEKK5 (MAP3K5) is a key kinase for our innate immunity and for mediating cellular signaling cascades evoked by changes in the external cellular environment. As such, MEKK5 is critical for cell fate during development, apoptosis, and cell survival as well as in modulating the host defense responses from a wide range of pathogens. MEKK5 acts as an upstream activator of the MKK/JNK signaling pathways and the p38 MAPK signaling pathways that ultimately results in activating multiple kinases such as MAP2K3/Mkk3 or MKK6/MMK7. Activation of MMEKK5 is via phosphorylation of Thr-845 within the activation loop via the recently discovered kinase MAP3K6 which forms a complex with MEKK5 and also stabilizes the protein. Expression is widespread and localized in the cytoplasmic in the perinuclear endoplasmic reticulum region.

Immunogène

linear peptide corresponding to Human phospho MEKK5 (Thr 845).

Application

Anti-phospho MEKK5, (Thr845), clone PA214 | MABS494 is an antibody against phospho MEKK5 for use in Western Blotting.

Research Category
Signaling

Research Sub Category
Immunological Signaling

Qualité

Evaluated by Western Blotting on HEK293A lysate
Western Blotting Analysis: 4 µg/mL dilution of this antibody detected phosphorylated MEKK5 protein in 10 µg of H2O2 treated Hek293A cell lysate

Description de la cible

~160 kDa observed

Forme physique

Format: Purified

Protein G Purified

Purified rabbit monoclonal supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to lot specific datasheet.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable